| pubmed-article:15851028 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15851028 | lifeskim:mentions | umls-concept:C0032098 | lld:lifeskim |
| pubmed-article:15851028 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15851028 | lifeskim:mentions | umls-concept:C0005495 | lld:lifeskim |
| pubmed-article:15851028 | lifeskim:mentions | umls-concept:C1956355 | lld:lifeskim |
| pubmed-article:15851028 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15851028 | pubmed:dateCreated | 2005-4-26 | lld:pubmed |
| pubmed-article:15851028 | pubmed:abstractText | Plants and animals use small RNAs (microRNAs [miRNAs] and siRNAs) as guides for posttranscriptional and epigenetic regulation. In plants, miRNAs and trans-acting (ta) siRNAs form through distinct biogenesis pathways, although they both interact with target transcripts and guide cleavage. An integrated approach to identify targets of Arabidopsis thaliana miRNAs and ta-siRNAs revealed several new classes of small RNA-regulated genes, including conventional genes such as Argonaute2 and an E2-ubiquitin conjugating enzyme. Surprisingly, five ta-siRNA-generating transcripts were identified as targets of miR173 or miR390. Rather than functioning as negative regulators, miR173- and miR390-guided cleavage was shown to set the 21-nucleotide phase for ta-siRNA precursor processing. These data support a model in which miRNA-guided formation of a 5' or 3' terminus within pre-ta-siRNA transcripts, followed by RDR6-dependent formation of dsRNA and Dicer-like processing, yields phased ta-siRNAs that negatively regulate other genes. | lld:pubmed |
| pubmed-article:15851028 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851028 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15851028 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851028 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15851028 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851028 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15851028 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15851028 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:15851028 | pubmed:author | pubmed-author:CarringtonJam... | lld:pubmed |
| pubmed-article:15851028 | pubmed:author | pubmed-author:MessmerBruno... | lld:pubmed |
| pubmed-article:15851028 | pubmed:author | pubmed-author:XieZhixinZ | lld:pubmed |
| pubmed-article:15851028 | pubmed:author | pubmed-author:GustafsonAdam... | lld:pubmed |
| pubmed-article:15851028 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15851028 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:15851028 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:15851028 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15851028 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15851028 | pubmed:pagination | 207-21 | lld:pubmed |
| pubmed-article:15851028 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15851028 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15851028 | pubmed:articleTitle | microRNA-directed phasing during trans-acting siRNA biogenesis in plants. | lld:pubmed |
| pubmed-article:15851028 | pubmed:affiliation | Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331, USA. | lld:pubmed |
| pubmed-article:15851028 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15851028 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15851028 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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