| pubmed-article:1584760 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C0029205 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C0947647 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1584760 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:1584760 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1584760 | pubmed:dateCreated | 1992-6-16 | lld:pubmed |
| pubmed-article:1584760 | pubmed:abstractText | A recently described organ culture system for human thymocytes is shown to support the generation of a diverse T-cell receptor repertoire in vitro: thymocytes of the alpha beta lineage, including representatives of the V beta families 5.2/5.3, 6.7, and 8, accounted for the majority of T-cell receptor-positive cells throughout a 3-week culture period. Thymocytes bearing gamma delta receptors were also identified, particularly among the CD4 CD8 double-negative subset. The T-cell receptor repertoire expressed in organ culture responded to experimental manipulation with staphylococcal enterotoxins. Staphylococcal enterotoxin D (a powerful activator of human peripheral T cells expressing V beta 5.2/5.3 receptors) caused a marked reduction of V beta 5.2/5.3 expression, as determined with the V beta-specific antibody 42/1C1. Evidence is presented that this loss of V beta 5.2/5.3 expression resulted from the selective deletion of activated thymocytes by apoptosis, in concert with T-cell receptor modulation. These effects of staphylococcal enterotoxin D were specific (since staphylococcal enterotoxin E did not influence V beta 5.2/5.3 expression) and V beta-selective (since expression of V beta 6.7 remained unaffected by staphylococcal enterotoxin D). On the basis of these observations, we suggest that thymic organ culture provides a powerful approach to study the generation of the human T-cell repertoire. | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1584760 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1584760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1584760 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1584760 | pubmed:month | May | lld:pubmed |
| pubmed-article:1584760 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1584760 | pubmed:author | pubmed-author:Merkenschlage... | lld:pubmed |
| pubmed-article:1584760 | pubmed:author | pubmed-author:FisherA GAG | lld:pubmed |
| pubmed-article:1584760 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1584760 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1584760 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1584760 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1584760 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1584760 | pubmed:pagination | 4255-9 | lld:pubmed |
| pubmed-article:1584760 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:meshHeading | pubmed-meshheading:1584760-... | lld:pubmed |
| pubmed-article:1584760 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1584760 | pubmed:articleTitle | Selective manipulation of the human T-cell receptor repertoire expressed by thymocytes in organ culture. | lld:pubmed |
| pubmed-article:1584760 | pubmed:affiliation | Department of Immunology, Institute de Chimie Biologique, Strasbourg, France. | lld:pubmed |
| pubmed-article:1584760 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1584760 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1584760 | lld:pubmed |
