| pubmed-article:15842965 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0010068 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0015663 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0360714 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0914069 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0376674 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0286651 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C0006560 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:15842965 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15842965 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15842965 | pubmed:dateCreated | 2005-4-21 | lld:pubmed |
| pubmed-article:15842965 | pubmed:abstractText | The effects of atorvastatin (40 mg/day) versus placebo on fasting and postprandial plasma levels of high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) were examined over 36 weeks in 84 patients who had coronary heart disease and low-density lipoprotein cholesterol levels >130 mg/dl and compared directly with the effects of fluvastatin, lovastatin, pravastatin, and simvastatin. Results were also compared with those obtained in age- and gender-matched control subjects (n = 84). Feeding increased median hs-CRP levels by 2% in patients (p = NS) and 22% in controls (p <0.01) and increased mean Lp-PLA2 values by 9% in patients (p = NS) but decreased values by 21% in controls (p <0.0001). Patients had 51% higher median hs-CRP values and 29% higher mean Lp-PLA2 values than did controls (p <0.05 for hs-CRP and Lp-PLA2) in the fasting state; however, Lp-PLA2 values were 62% higher (p <0.0001) in the fed state in patients compared with controls. Atorvastatin decreased median hs-CRP levels by 32% (p <0.01) and mean Lp-PLA2 values by 26% in patients (p <0.0001), with similar decreases in the fed state, and none of the other statins had any significant effect on these parameters. Change in Lp-PLA2 was significantly related to change in low-density lipoprotein cholesterol (p <0.01), with no significant relations with change in hs-CRP. Our data indicate greater differences in patients with coronary heart disease compared with controls in Lp-PLA2 in the fed state than in the fasting state and that atorvastatin is more effective than fluvastatin, lovastatin, pravastatin, or simvastatin for decreasing not only low-density lipoprotein cholesterol but also hs-CRP and Lp-PLA2. | lld:pubmed |
| pubmed-article:15842965 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15842965 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15842965 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15842965 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15842965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15842965 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15842965 | pubmed:month | May | lld:pubmed |
| pubmed-article:15842965 | pubmed:issn | 0002-9149 | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:SchaeferErnst... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:FerrariAndrea... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:McNamaraJudit... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:AsztalosBela... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:TaylerTimothy... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:DalyJennifer... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:SemanLeo JLJ | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:RubensteinJoe... | lld:pubmed |
| pubmed-article:15842965 | pubmed:author | pubmed-author:GleasonJoi... | lld:pubmed |
| pubmed-article:15842965 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15842965 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15842965 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:15842965 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15842965 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15842965 | pubmed:pagination | 1025-32 | lld:pubmed |
| pubmed-article:15842965 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15842965 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15842965 | pubmed:articleTitle | Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjects. | lld:pubmed |
| pubmed-article:15842965 | pubmed:affiliation | Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA. ernst.schaefer@tufts.edu | lld:pubmed |
| pubmed-article:15842965 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15842965 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15842965 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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