| pubmed-article:15841185 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15841185 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15841185 | lifeskim:mentions | umls-concept:C0242488 | lld:lifeskim |
| pubmed-article:15841185 | lifeskim:mentions | umls-concept:C0524828 | lld:lifeskim |
| pubmed-article:15841185 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:15841185 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:15841185 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:15841185 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15841185 | pubmed:dateCreated | 2005-4-20 | lld:pubmed |
| pubmed-article:15841185 | pubmed:abstractText | Hyperoxic acute lung injury (HALI) is characterized by a cell death response with features of apoptosis and necrosis that is inhibited by IL-11 and other interventions. We hypothesized that Bfl-1/A1, an antiapoptotic Bcl-2 protein, is a critical regulator of HALI and a mediator of IL-11-induced cytoprotection. To test this, we characterized the expression of A1 and the oxygen susceptibility of WT and IL-11 Tg(+) mice with normal and null A1 loci. In WT mice, 100% O(2) caused TUNEL(+) cell death, induction and activation of intrinsic and mitochondrial-death pathways, and alveolar protein leak. Bcl-2 and Bcl-xl were also induced as an apparent protective response. A1 was induced in hyperoxia, and in A1-null mice, the toxic effects of hyperoxia were exaggerated, Bcl-2 and Bcl-xl were not induced, and premature death was seen. In contrast, IL-11 stimulated A1, diminished the toxic effects of hyperoxia, stimulated Bcl-2 and Bcl-xl, and enhanced murine survival in 100% O(2). In A1-null mice, IL-11-induced protection, survival advantage, and Bcl-2 and Bcl-xl induction were significantly decreased. VEGF also conferred protection via an A1-dependent mechanism. In vitro hyperoxia also stimulated A1, and A1 overexpression inhibited oxidant-induced epithelial cell apoptosis and necrosis. A1 is an important regulator of oxidant-induced lung injury, apoptosis, necrosis, and Bcl-2 and Bcl-xl gene expression and a critical mediator of IL-11- and VEGF-induced cytoprotection. | lld:pubmed |
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| pubmed-article:15841185 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15841185 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15841185 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15841185 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15841185 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15841185 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:NakayamaKeiko... | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:ZhuZhouZ | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:MaBingB | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:LeeChun... | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:EliasJack AJA | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:NakayamaKeiic... | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:ZhongMeiM | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:LinkHolgerH | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:ChenQingsheng... | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:RabachMorgan... | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:HomerRobertR | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:WaxmanAaron... | lld:pubmed |
| pubmed-article:15841185 | pubmed:author | pubmed-author:HeChuan HuaCH | lld:pubmed |
| pubmed-article:15841185 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15841185 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:15841185 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15841185 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15841185 | pubmed:pagination | 1039-48 | lld:pubmed |
| pubmed-article:15841185 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15841185 | pubmed:meshHeading | pubmed-meshheading:15841185... | lld:pubmed |
