| pubmed-article:15838654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0023470 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0752063 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0623362 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C1150224 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15838654 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15838654 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15838654 | pubmed:dateCreated | 2005-7-27 | lld:pubmed |
| pubmed-article:15838654 | pubmed:abstractText | Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is one of the best characterized nuclear hormone receptors (NHRs) in the superfamily of ligand-activated transcriptional factors. PPAR-gamma ligands have recently been demonstrated to affect proliferation, differentiation and apoptosis of different cell types. The present study was undertaken to investigate PPAR-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase MMP-9 and MMP-2 activities on leukemia K562 and HL-60 cells in vitro. The results revealed that PPAR-gamma expression was detectable in the two kinds of leukemia cells; Both 15-deoxy-delta(12,14)-prostaglandin J2(15d-PGJ2) and troglitazone (TGZ) have significant growth inhibition effects on these two kinds of leukemia cells. These two PPAR-gamma ligands could inhibit the leukemic cell adhesion to the extracellular matrix (ECM) proteins and the invasion through matrigel matrix. The expressions of MMP-9 and MMP-2 as well as their gelatinolytic activities in both HL-60 and K562 cells were inhibited by 15d-PGJ2 and TGZ significantly. We therefore conclude that PPAR-gamma ligands 15d-PGJ2 and TGZ have significant growth inhibition effects on myeloid leukemia cells in vitro, and that PPAR-gamma ligands can inhibit K562 and HL-60 cell adhesion to and invasion through ECM as well as downregulate MMP-9 and MMP-2 expressions. The data suggest that PPAR-gamma ligands may serve as potential anti-leukemia reagents. | lld:pubmed |
| pubmed-article:15838654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15838654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15838654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15838654 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15838654 | pubmed:issn | 0344-5704 | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:YuZ PZP | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:LoolA LAL | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:ZhengJingJ | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:WuXinyaoX | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:HouMingM | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:ZhangMaohongM | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:LuHuilingH | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:QuLinL | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:PanXianglinX | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:LiuJiajunJ | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:HuangRenweiR | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:LinDongjunD | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:WuXiangyuanX | lld:pubmed |
| pubmed-article:15838654 | pubmed:author | pubmed-author:SongYuqinY | lld:pubmed |
| pubmed-article:15838654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15838654 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:15838654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15838654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15838654 | pubmed:pagination | 400-8 | lld:pubmed |
| pubmed-article:15838654 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:meshHeading | pubmed-meshheading:15838654... | lld:pubmed |
| pubmed-article:15838654 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15838654 | pubmed:articleTitle | Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. | lld:pubmed |
| pubmed-article:15838654 | pubmed:affiliation | Department of Haematology and Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Guangzhou, 510630, P.R. China, liujj@gzsums.edu.cn. | lld:pubmed |
| pubmed-article:15838654 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15838654 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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