| pubmed-article:15837817 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15837817 | lifeskim:mentions | umls-concept:C0205734 | lld:lifeskim |
| pubmed-article:15837817 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:15837817 | lifeskim:mentions | umls-concept:C1515406 | lld:lifeskim |
| pubmed-article:15837817 | lifeskim:mentions | umls-concept:C0597452 | lld:lifeskim |
| pubmed-article:15837817 | lifeskim:mentions | umls-concept:C0442797 | lld:lifeskim |
| pubmed-article:15837817 | lifeskim:mentions | umls-concept:C2698594 | lld:lifeskim |
| pubmed-article:15837817 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15837817 | pubmed:dateCreated | 2005-4-19 | lld:pubmed |
| pubmed-article:15837817 | pubmed:abstractText | Natural CD4(+)CD25(+) regulatory T (CD4(+)CD25(+) T reg) cells play a key role in the immunoregulation of autoimmunity. However, little is known about the interactions between CD4(+)CD25(+) T reg cells and autoreactive T cells. This is due, in part, to the difficulty of using cell surface markers to identify CD4(+)CD25(+) T reg cells accurately. Using a novel real-time PCR assay, mRNA copy number of FoxP3, TGFbeta1, and interleukin (IL)-10 was measured in single cells to characterize and quantify CD4(+)CD25(+) T reg cells in the nonobese diabetic (NOD) mouse, a murine model for type 1 diabetes (T1D). The suppressor function of CD4(+)CD25(+)CD62L(hi) T cells, mediated by TGFbeta, declined in an age-dependent manner. This loss of function coincided with a temporal decrease in the percentage of FoxP3 and TGFbeta1 coexpressing T cells within pancreatic lymph node and islet infiltrating CD4(+)CD25(+)CD62L(hi) T cells, and was detected in female NOD mice but not in NOD male mice, or NOR or C57BL/6 female mice. These results demonstrate that the majority of FoxP3-positive CD4(+)CD25(+) T reg cells in NOD mice express TGFbeta1 but not IL-10, and that a defect in the maintenance and/or expansion of this pool of immunoregulatory effectors is associated with the progression of T1D. | lld:pubmed |
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| pubmed-article:15837817 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15837817 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15837817 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15837817 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15837817 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15837817 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15837817 | pubmed:author | pubmed-author:ClarkeStephen... | lld:pubmed |
| pubmed-article:15837817 | pubmed:author | pubmed-author:TischRolandR | lld:pubmed |
| pubmed-article:15837817 | pubmed:author | pubmed-author:WongCarmen... | lld:pubmed |
| pubmed-article:15837817 | pubmed:author | pubmed-author:PopShannon... | lld:pubmed |
| pubmed-article:15837817 | pubmed:author | pubmed-author:CultonDonna... | lld:pubmed |
| pubmed-article:15837817 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15837817 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:15837817 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:15837817 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15837817 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15837817 | pubmed:pagination | 1333-46 | lld:pubmed |
| pubmed-article:15837817 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15837817 | pubmed:year | 2005 | lld:pubmed |
