| pubmed-article:1583736 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C1335858 | lld:lifeskim |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C0039341 | lld:lifeskim |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C2755756 | lld:lifeskim |
| pubmed-article:1583736 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1583736 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1583736 | pubmed:dateCreated | 1992-6-16 | lld:pubmed |
| pubmed-article:1583736 | pubmed:abstractText | We have previously shown that the human immunodeficiency virus type 1 (HIV-1) Tat protein can activate a synthetic promoter containing consensus-binding sites for the cellular transcription factor Sp1. In this report, we show that a GAL-Tat fusion protein targeted via GAL4 DNA-binding sites can also trans activate an HIV-1 LTR promoter independently of the trans-activation response region. To show that the trans activation of the promoter by Tat directly involves the Sp1 protein, we have targeted a GAL-Sp1 fusion protein to the long terminal repeat promoter via upstream GAL4-binding sites. In the presence of Tat and GAL-Sp1, the promoter is synergistically trans activated at the transcriptional level, indicating that Tat and Sp1 functionally interact to trans activate the HIV-1 promoter. The Sp1 synergism is relatively specific, since another chimeric transcriptional activator, GAL-VP16, does not appear to be significantly synergistic with Tat. | lld:pubmed |
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| pubmed-article:1583736 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1583736 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1583736 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1583736 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1583736 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1583736 | pubmed:author | pubmed-author:KamineJJ | lld:pubmed |
| pubmed-article:1583736 | pubmed:author | pubmed-author:ChinnaduraiGG | lld:pubmed |
| pubmed-article:1583736 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1583736 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1583736 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1583736 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1583736 | pubmed:pagination | 3932-6 | lld:pubmed |
| pubmed-article:1583736 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1583736 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1583736 | pubmed:articleTitle | Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1. | lld:pubmed |
| pubmed-article:1583736 | pubmed:affiliation | Institute for Molecular Virology, St. Louis University School of Medicine, Missouri 63110. | lld:pubmed |
| pubmed-article:1583736 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1583736 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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