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pubmed-article:15837309pubmed:abstractTextA series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.lld:pubmed
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pubmed-article:15837309pubmed:articleTitleAnalogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.lld:pubmed
pubmed-article:15837309pubmed:affiliationInstituto de Química Médica, Juan de la Cierva, 3, 28006 Madrid, Spain.lld:pubmed
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