| pubmed-article:1582416 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1582416 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1582416 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1582416 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:1582416 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1582416 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:1582416 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:1582416 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1582416 | pubmed:dateCreated | 1992-6-16 | lld:pubmed |
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| pubmed-article:1582416 | pubmed:abstractText | The human interleukin-3 receptor (IL-3R) is composed of an IL-3 specific alpha subunit (IL-3R alpha) and a common beta subunit (beta c) that is shared by IL-3, granulocyte/macrophage colony stimulating factor (GM-CSF) and IL-5 receptors. In contrast to the human, the mouse has two distinct but related genes, AIC2A and AIC2B, both of which are homologous to the human beta c gene. AIC2B has proved to encode a common beta subunit between mouse GM-CSF and IL-5 receptors. AIC2A is unique to the mouse and encodes a low affinity IL-3 binding protein. Based on the observation that the AIC2A protein is a component of a high affinity IL-3R, we searched for a cDNA encoding a protein which conferred high affinity IL-3 binding when coexpressed with the AIC2A protein in COS7 cells. We obtained such a cDNA (SUT-1) encoding a mature protein of 70 kDa that has weak homology to the human IL-3R alpha. The SUT-1 protein bound IL-3 with low affinity and formed high affinity receptors not only with the AIC2A protein but also with the AIC2B protein. Both high affinity IL-3Rs expressed on a mouse T cell line, CTLL-2, showed similar IL-3 binding properties and transmitted a growth signal in response to IL-3. Thus, the mouse has two distinct functional high affinity IL-3Rs, providing a molecular explanation for the differences observed between mouse and human IL-3Rs. | lld:pubmed |
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| pubmed-article:1582416 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1582416 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1582416 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1582416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1582416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1582416 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1582416 | pubmed:month | May | lld:pubmed |
| pubmed-article:1582416 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:1582416 | pubmed:author | pubmed-author:HaraTT | lld:pubmed |
| pubmed-article:1582416 | pubmed:author | pubmed-author:MiyajimaAA | lld:pubmed |
| pubmed-article:1582416 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1582416 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1582416 | pubmed:geneSymbol | AIC2B | lld:pubmed |
| pubmed-article:1582416 | pubmed:geneSymbol | AIC2A | lld:pubmed |
| pubmed-article:1582416 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1582416 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1582416 | pubmed:pagination | 1875-84 | lld:pubmed |
| pubmed-article:1582416 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1582416 | pubmed:meshHeading | pubmed-meshheading:1582416-... | lld:pubmed |
| pubmed-article:1582416 | pubmed:meshHeading | pubmed-meshheading:1582416-... | lld:pubmed |
| pubmed-article:1582416 | pubmed:meshHeading | pubmed-meshheading:1582416-... | lld:pubmed |
| pubmed-article:1582416 | pubmed:meshHeading | pubmed-meshheading:1582416-... | lld:pubmed |
