| pubmed-article:15824068 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15824068 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:15824068 | lifeskim:mentions | umls-concept:C0678544 | lld:lifeskim |
| pubmed-article:15824068 | lifeskim:mentions | umls-concept:C0301875 | lld:lifeskim |
| pubmed-article:15824068 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:15824068 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15824068 | pubmed:dateCreated | 2005-4-27 | lld:pubmed |
| pubmed-article:15824068 | pubmed:abstractText | Memory B cells can be generated independently of germinal center (GC) formation and affinity maturation in Bcl-6-deficient mice, but the contribution of the GC-independent pathway for memory B-cell generation in normal mice remains unknown. To examine this, we administrated anti-inducible co-stimulator (ICOS) mAbs into mice at the onset of GC formation in the primary response. This manipulation affected the generation of GC B cells in the spleen, but neither IgG1 memory B cell nor production of IgG1 long-term antibody was affected. In ICOS-manipulated mice, GC B cells accumulated somatic mutations in the IgV(H) genes and underwent affinity maturation; however, memory B cells scarcely accumulated mutations and reconstituted the secondary response by low affinity, supporting the notion that low-affinity memory B cells are generated in a GC-independent manner. Thus, it appears that memory B cells are established by two different pathways, associated with or without GC reaction and affinity maturation. The generation and long-term persistence of low-affinity IgG1 memory B cells and antibodies in ICOS-manipulated mice support the idea that low-affinity memory B cells may give rise to long-term antibody-forming cells. | lld:pubmed |
| pubmed-article:15824068 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15824068 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15824068 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15824068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15824068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15824068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15824068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15824068 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15824068 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15824068 | pubmed:month | May | lld:pubmed |
| pubmed-article:15824068 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:MiyakeKensuke... | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:TokuhisaTakes... | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:TakemoriToshi... | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:AbeRyoR | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:TakahashiYosh... | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:InamineAyakoA | lld:pubmed |
| pubmed-article:15824068 | pubmed:author | pubmed-author:BabaNobueN | lld:pubmed |
| pubmed-article:15824068 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15824068 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:15824068 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15824068 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15824068 | pubmed:pagination | 581-9 | lld:pubmed |
| pubmed-article:15824068 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:meshHeading | pubmed-meshheading:15824068... | lld:pubmed |
| pubmed-article:15824068 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15824068 | pubmed:articleTitle | Two waves of memory B-cell generation in the primary immune response. | lld:pubmed |
| pubmed-article:15824068 | pubmed:affiliation | Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. | lld:pubmed |
| pubmed-article:15824068 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15824068 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15824068 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15824068 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15824068 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15824068 | lld:pubmed |
