| pubmed-article:15821732 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15821732 | lifeskim:mentions | umls-concept:C0018042 | lld:lifeskim |
| pubmed-article:15821732 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:15821732 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:15821732 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:15821732 | lifeskim:mentions | umls-concept:C1159362 | lld:lifeskim |
| pubmed-article:15821732 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15821732 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15821732 | pubmed:dateCreated | 2005-5-3 | lld:pubmed |
| pubmed-article:15821732 | pubmed:abstractText | Cortactin is an actin-binding protein that has recently been implicated in endocytosis. It binds directly to dynamin-2 (Dyn2), a large GTPase that mediates the formation of vesicles from the plasma membrane and the Golgi. Here we show that cortactin associates with the Golgi to regulate the actin- and Dyn2-dependent transport of cargo. Cortactin antibodies stain the Golgi apparatus, labelling peripheral buds and vesicles that are associated with the cisternae. Notably, in vitro or intact-cell experiments show that activation of Arf1 mediates the recruitment of actin, cortactin and Dyn2 to Golgi membranes. Furthermore, selective disruption of the cortactin-Dyn2 interaction significantly reduces the levels of Dyn2 at the Golgi and blocks the transit of nascent proteins from the trans-Golgi network, resulting in swollen and distended cisternae. These findings support the idea of an Arf1-activated recruitment of an actin, cortactin and Dyn2 complex that is essential for Golgi function. | lld:pubmed |
| pubmed-article:15821732 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15821732 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15821732 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15821732 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15821732 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15821732 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15821732 | pubmed:month | May | lld:pubmed |
| pubmed-article:15821732 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:HornE MEM | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:ChenJingJ | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:OrthJames DJD | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:McNivenMark... | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:HuangBingB | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:ChenJi-LongJL | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:StamnesMarkM | lld:pubmed |
| pubmed-article:15821732 | pubmed:author | pubmed-author:WellerShaunS | lld:pubmed |
| pubmed-article:15821732 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15821732 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15821732 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15821732 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15821732 | pubmed:pagination | 483-92 | lld:pubmed |
| pubmed-article:15821732 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15821732 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15821732 | pubmed:articleTitle | Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. | lld:pubmed |
| pubmed-article:15821732 | pubmed:affiliation | Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA. | lld:pubmed |
| pubmed-article:15821732 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15821732 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15821732 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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