| pubmed-article:15813930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15813930 | lifeskim:mentions | umls-concept:C0014038 | lld:lifeskim |
| pubmed-article:15813930 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:15813930 | lifeskim:mentions | umls-concept:C0063710 | lld:lifeskim |
| pubmed-article:15813930 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:15813930 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:15813930 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15813930 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15813930 | pubmed:dateCreated | 2005-4-7 | lld:pubmed |
| pubmed-article:15813930 | pubmed:abstractText | Most pathologies of the brain have an inflammatory component, associated with the release of cytokines such as interleukin-1beta (IL-1beta) from resident and infiltrating cells. The IL-1 type I receptor (IL-1RI) initiates a signalling cascade but the type II receptor (IL-1RII) acts as a decoy receptor. Here we have investigated the expression of IL-1beta, IL-1RI and IL-1RII in distinct inflammatory lesions in the rat brain. IL-1beta was injected into the brain to generate an inflammatory lesion in the absence of neuronal cell death whereas neuronal death was specifically induced by the microinjection of N-methyl-D-aspartate (NMDA). Using TaqMan RT-PCR and ELISA, we observed elevated de novo IL-1beta synthesis 2 h after the intracerebral microinjection of IL-1beta; this de novo IL-1beta remained elevated 24 h later. There was a concomitant increase in IL-1RI mRNA but a much greater increase in IL-1RII mRNA. Immunostaining revealed that IL-1RII was expressed on brain endothelial cells and on infiltrating neutrophils. In contrast, although IL-1beta and IL-1RI were elevated to similar levels in response to NMDA challenge, the response was delayed and IL-1RII mRNA expression was unchanged. The lesion-specific expression of IL-1 receptors suggests that the receptors are differentially regulated in a manner not directly related to the endogenous level of IL-1 in the CNS. | lld:pubmed |
| pubmed-article:15813930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15813930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15813930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15813930 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15813930 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:GuazaCarmenC | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:PooleStephenS | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:PerryV HughVH | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:CampbellSandr... | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:AnthonyDaniel... | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:DocagneFabian... | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:BristowAdrian... | lld:pubmed |
| pubmed-article:15813930 | pubmed:author | pubmed-author:ViguesStephan... | lld:pubmed |
| pubmed-article:15813930 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15813930 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:15813930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15813930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15813930 | pubmed:pagination | 1205-14 | lld:pubmed |
| pubmed-article:15813930 | pubmed:dateRevised | 2006-11-20 | lld:pubmed |
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| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:meshHeading | pubmed-meshheading:15813930... | lld:pubmed |
| pubmed-article:15813930 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15813930 | pubmed:articleTitle | Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation. | lld:pubmed |
| pubmed-article:15813930 | pubmed:affiliation | Molecular Neuropathology Laboratory, School of Biological Sciences, University of Southampton, UK. docagne@cajal.csic.es | lld:pubmed |
| pubmed-article:15813930 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15813930 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15813930 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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