| pubmed-article:15793357 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15793357 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15793357 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:15793357 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:15793357 | lifeskim:mentions | umls-concept:C0030425 | lld:lifeskim |
| pubmed-article:15793357 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15793357 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15793357 | pubmed:dateCreated | 2005-3-28 | lld:pubmed |
| pubmed-article:15793357 | pubmed:abstractText | Eosinophil degranulation is considered to be a key effector function for the killing of helminthic worms and tissue inflammation at worm-infected lesion sites. However, relatively little data are available with regard to eosinophil response after stimulation with worm-secreted products which contain a large quantity of cysteine proteases. In this study, we attempted to determine whether the degranulation of human eosinophils could be induced by the direct stimulation of the excretory-secretory products (ESP) of Paragonimus westermani, which causes pulmonary paragonimiasis in human beings. Incubation of eosinophils for 3 hr with Paragonimus-secreted products resulted in marked degranulation, as evidenced by the release of eosinophil-derived neurotoxin (EDN) in the culture supernatants. Moreover, superoxide anion was produced by eosinophils after stimulation of the ESP. The ESP-induced EDN release was found to be significantly inhibited when the ESP was pretreated with protease inhibitor cocktail or the cysteine protease inhibitor, E-64. These findings suggest that human eosinophils become degranulated in response to P. westermani-secreted proteases, which may contribute to in vivo tissue inflammation around the worms. | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15793357 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15793357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793357 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15793357 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15793357 | pubmed:issn | 0023-4001 | lld:pubmed |
| pubmed-article:15793357 | pubmed:author | pubmed-author:KitaHirohitoH | lld:pubmed |
| pubmed-article:15793357 | pubmed:author | pubmed-author:ShinMyeong... | lld:pubmed |
| pubmed-article:15793357 | pubmed:author | pubmed-author:ChungYoung-Ba... | lld:pubmed |
| pubmed-article:15793357 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15793357 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:15793357 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15793357 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15793357 | pubmed:pagination | 33-7 | lld:pubmed |
| pubmed-article:15793357 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:meshHeading | pubmed-meshheading:15793357... | lld:pubmed |
| pubmed-article:15793357 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15793357 | pubmed:articleTitle | Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease. | lld:pubmed |
| pubmed-article:15793357 | pubmed:affiliation | Department of Parasitology, Institute of Tropical Medicine, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea. myeong@yumc.yonsei.ac.kr | lld:pubmed |
| pubmed-article:15793357 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15793357 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15793357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15793357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15793357 | lld:pubmed |
