| pubmed-article:15793257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C0004048 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C1176237 | lld:lifeskim |
| pubmed-article:15793257 | lifeskim:mentions | umls-concept:C1707797 | lld:lifeskim |
| pubmed-article:15793257 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15793257 | pubmed:dateCreated | 2005-3-28 | lld:pubmed |
| pubmed-article:15793257 | pubmed:abstractText | The results of the present study, using the conscious beagle dog, demonstrate that inhaled insulin (INH; Exubera) provides better glycemic control during an intraportal glucose load than identical insulin levels induced by insulin (Humulin) infusion into the inferior vena cava (IVC). In the INH group (n = 13), portal glucose infusion caused arterial plasma glucose to rise transiently (152 +/- 9 mg/dl), before it returned to baseline (65 min) for the next 2 h. Net hepatic glucose uptake was minimal, whereas nonhepatic uptake rose to 12.5 +/- 0.5 mg x kg(-1) x min(-1) (65 min). In the IVC group (n = 9), arterial glucose rose rapidly (172 +/- 6 mg/dl) and transiently fell to 135 +/- 13 mg/dl (65 min) before returning to 165 +/- 15 mg/dl (125 min). Plasma glucose excursions and hepatic glucose uptake were much greater in the IVC group, whereas nonhepatic uptake was markedly less (8.6 +/- 0.9 mg x kg(-1) x min(-1); 65 min). Insulin kinetics and areas under the curve were identical in both groups. These data suggest that inhalation of Exubera results in a unique action on nonhepatic glucose clearance. | lld:pubmed |
| pubmed-article:15793257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15793257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793257 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15793257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15793257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15793257 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15793257 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:NealDoss WDW | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:CherringtonAl... | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:ScottMelanieM | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:EdgertonDale... | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:BowenLarryL | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:HobbsCharles... | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:LeachChetC | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:StrackThomas... | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:WilsonWarrenW | lld:pubmed |
| pubmed-article:15793257 | pubmed:author | pubmed-author:SivakumaranSh... | lld:pubmed |
| pubmed-article:15793257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15793257 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:15793257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15793257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15793257 | pubmed:pagination | 1164-70 | lld:pubmed |
| pubmed-article:15793257 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:meshHeading | pubmed-meshheading:15793257... | lld:pubmed |
| pubmed-article:15793257 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15793257 | pubmed:articleTitle | Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. | lld:pubmed |
| pubmed-article:15793257 | pubmed:affiliation | Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 710 Robinson Research Bldg., Nashville, TN 37232-0615, USA. dale.edgerton@vanderbilt.edu | lld:pubmed |
| pubmed-article:15793257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15793257 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15793257 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15793257 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15793257 | lld:pubmed |
