| pubmed-article:15790758 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15790758 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:15790758 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:15790758 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:15790758 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:15790758 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15790758 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15790758 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15790758 | pubmed:dateCreated | 2005-6-17 | lld:pubmed |
| pubmed-article:15790758 | pubmed:abstractText | Salmonella-epithelial cell interactions are known to activate the proinflammatory NF-kappaB signaling pathway and have recently been found to also influence the beta-catenin signaling pathway, an important regulator of epithelial cell proliferation and differentiation. Here, using polarized epithelial cell models, we demonstrate that these same bacteria-mediated effects also direct the molecular crosstalk between the NF-kappaB and beta-catenin signaling pathways. Convergence of these two pathways is a result of the direct interaction between the NF-kappaB p50 subunit and beta-catenin. We show that PhoP(c), the avirulent derivative of a wild-type Salmonella strain, attenuates NF-kappaB activity by stabilizing the association of beta-catenin with NF-kappaB. In cell lines expressing constitutively active beta-catenin, IkappaBalpha protein was indirectly stabilized and NF-kappaB activity was repressed after wild-type Salmonella colonization. Accordingly, constitutively active beta-catenin was found to inhibit the secretion of IL-8. Thus our findings strongly suggest that the crosstalk between the beta-catenin and NF-kappaB signaling pathways is an important regulator of intestinal inflammation. | lld:pubmed |
| pubmed-article:15790758 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15790758 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15790758 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15790758 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15790758 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15790758 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15790758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15790758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15790758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15790758 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15790758 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15790758 | pubmed:issn | 0193-1857 | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:TagM HMH | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:HobertMichael... | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:MadaraJames... | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:HeTong-ChuanT... | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:ChangEugene... | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:RaoAnjali SAS | lld:pubmed |
| pubmed-article:15790758 | pubmed:author | pubmed-author:DuanYingliY | lld:pubmed |
| pubmed-article:15790758 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15790758 | pubmed:volume | 289 | lld:pubmed |
| pubmed-article:15790758 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15790758 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15790758 | pubmed:pagination | G129-37 | lld:pubmed |
| pubmed-article:15790758 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15790758 | pubmed:meshHeading | pubmed-meshheading:15790758... | lld:pubmed |
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| pubmed-article:15790758 | pubmed:meshHeading | pubmed-meshheading:15790758... | lld:pubmed |
| pubmed-article:15790758 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15790758 | pubmed:articleTitle | Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. | lld:pubmed |
| pubmed-article:15790758 | pubmed:affiliation | Department of Pathology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA. jsun@bsd.uchicago.edu | lld:pubmed |
| pubmed-article:15790758 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15790758 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15790758 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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