| pubmed-article:15789863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15789863 | lifeskim:mentions | umls-concept:C0001948 | lld:lifeskim |
| pubmed-article:15789863 | lifeskim:mentions | umls-concept:C0205653 | lld:lifeskim |
| pubmed-article:15789863 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:15789863 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:15789863 | lifeskim:mentions | umls-concept:C0686907 | lld:lifeskim |
| pubmed-article:15789863 | pubmed:dateCreated | 2005-3-25 | lld:pubmed |
| pubmed-article:15789863 | pubmed:abstractText | This chapter reviews findings, mainly obtained from the selectively bred alcohol-preferring (P) line of rats, on (a) the development of alcohol drinking during the peri-adolescent period, (b) neurobiological factors that may contribute to adolescent drinking, (c) interventions to prevent alcohol drinking during adolescence, and (d) some long-lasting consequences of adolescent alcohol drinking. The findings indicate that P rats readily initiate alcohol drinking during the early post-weaning, adolescent and peri-adolescent periods of development. The early age-of-onset of alcohol drinking in the P compared to the NP line is associated with (a) higher densities of serotonin-1A (5-HT1A) receptors in cerebral cortical and hippocampal regions; (b) lower densities of dopamine (DA) D2 receptors in the ventral tegmental area (VTA); (c) higher functional activity in several limbic, cortical and hippocampal regions; and (d) sensitivity to the low-dose stimulating effect of ethanol. Conditioned taste aversion (CTA) training during adolescence produces long-term effects on preventing high alcohol drinking behavior of P rats. Alcohol drinking during peri-adolescence by P rats produces long-lasting effects that increase the acquisition of ethanol self-administration in adulthood, and, in addition, increase craving-like behavior and the potential for alcohol relapse. With suitable animal models, a better understanding of the mechanisms underlying adolescent alcohol drinking and its long-range consequences can be attained. | lld:pubmed |
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| pubmed-article:15789863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15789863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15789863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15789863 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15789863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15789863 | pubmed:issn | 0738-422X | lld:pubmed |
| pubmed-article:15789863 | pubmed:author | pubmed-author:McBrideWillia... | lld:pubmed |
| pubmed-article:15789863 | pubmed:author | pubmed-author:MurphyJames... | lld:pubmed |
| pubmed-article:15789863 | pubmed:author | pubmed-author:BellRichard... | lld:pubmed |
| pubmed-article:15789863 | pubmed:author | pubmed-author:StrotherWendy... | lld:pubmed |
| pubmed-article:15789863 | pubmed:author | pubmed-author:RoddZachary... | lld:pubmed |
| pubmed-article:15789863 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15789863 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:15789863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15789863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15789863 | pubmed:pagination | 123-42 | lld:pubmed |
| pubmed-article:15789863 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15789863 | pubmed:meshHeading | pubmed-meshheading:15789863... | lld:pubmed |
| pubmed-article:15789863 | pubmed:meshHeading | pubmed-meshheading:15789863... | lld:pubmed |
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| pubmed-article:15789863 | pubmed:meshHeading | pubmed-meshheading:15789863... | lld:pubmed |
| pubmed-article:15789863 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15789863 | pubmed:articleTitle | Adolescent alcohol drinking and its long-range consequences. Studies with animal models. | lld:pubmed |
| pubmed-article:15789863 | pubmed:affiliation | Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana 46202-4887, USA. | lld:pubmed |
| pubmed-article:15789863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15789863 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15789863 | pubmed:publicationType | Review | lld:pubmed |
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