| pubmed-article:15788704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15788704 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:15788704 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15788704 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:15788704 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15788704 | pubmed:dateCreated | 2005-3-24 | lld:pubmed |
| pubmed-article:15788704 | pubmed:abstractText | Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein-coupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat stomach and named it "ghrelin," after a word root ("ghre") in Proto-Indo-European languages meaning "grow." Ghrelin is a peptide hormone in which the third amino acid, usually a serine but in some species a threonine, is modified by a fatty acid; this modification is essential for ghrelin's activity. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by ghrelin derived from the stomach. In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. Ghrelin is orexigenic; it is secreted from the stomach and circulates in the bloodstream under fasting conditions, indicating that it transmits a hunger signal from the periphery to the central nervous system. Taking into account all these activities, ghrelin plays important roles for maintaining GH release and energy homeostasis in vertebrates. | lld:pubmed |
| pubmed-article:15788704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15788704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15788704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15788704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15788704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15788704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15788704 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15788704 | pubmed:issn | 0031-9333 | lld:pubmed |
| pubmed-article:15788704 | pubmed:author | pubmed-author:KojimaMasayas... | lld:pubmed |
| pubmed-article:15788704 | pubmed:author | pubmed-author:KangawaKenjiK | lld:pubmed |
| pubmed-article:15788704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15788704 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:15788704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15788704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15788704 | pubmed:pagination | 495-522 | lld:pubmed |
| pubmed-article:15788704 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15788704 | pubmed:meshHeading | pubmed-meshheading:15788704... | lld:pubmed |
| pubmed-article:15788704 | pubmed:meshHeading | pubmed-meshheading:15788704... | lld:pubmed |
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| pubmed-article:15788704 | pubmed:meshHeading | pubmed-meshheading:15788704... | lld:pubmed |
| pubmed-article:15788704 | pubmed:meshHeading | pubmed-meshheading:15788704... | lld:pubmed |
| pubmed-article:15788704 | pubmed:meshHeading | pubmed-meshheading:15788704... | lld:pubmed |
| pubmed-article:15788704 | pubmed:meshHeading | pubmed-meshheading:15788704... | lld:pubmed |
| pubmed-article:15788704 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15788704 | pubmed:articleTitle | Ghrelin: structure and function. | lld:pubmed |
| pubmed-article:15788704 | pubmed:affiliation | Molecular Genetics, Institute of Life Science, Kurume University, Hyakunenkouen 1-1, Kurume, Fukuoka 839-0864, Japan. mkojima@lsi.kurume-u.ac.jp | lld:pubmed |
| pubmed-article:15788704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15788704 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:15788704 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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