| pubmed-article:15786495 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C0081939 | lld:lifeskim |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C1335205 | lld:lifeskim |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C1820288 | lld:lifeskim |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15786495 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15786495 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15786495 | pubmed:dateCreated | 2005-5-16 | lld:pubmed |
| pubmed-article:15786495 | pubmed:abstractText | Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is widely used as a marker during vasculogenesis and angiogenesis from embryonic stem (ES) cells. However, the expression of PECAM-1 isoforms in ES cells has not been determined. The present study was designed to determine the role of PECAM-1 isoforms during in vitro endothelial differentiation of ES cells. It was found that undifferentiated ES cells expressed high level of PECAM-1, which primarily located at cell-cell junction, but the expression of PECAM-1 was sharply down-regulated during early ES cell differentiation. In addition, undifferentiated ES cells were found the expressed all eight known alternatively spliced PECAM-1 isoforms, among them the expression of PECAM-1 isoforms lacking exon 15 or 14&15 was predominant. Quantitative analysis revealed a significant increase in the expression of PECAM-1 isoform lacking exon 12&14&15 as vascular development of ES cells. These results indicate a constitutive expression of PECAM-1 in undifferentiated murine ES cells and suggest a developmental role of PECAM-1 isoform changes during vasculogenesis and angiogenesis. | lld:pubmed |
| pubmed-article:15786495 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15786495 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15786495 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15786495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15786495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15786495 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15786495 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15786495 | pubmed:issn | 0730-2312 | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:XuBinB | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:ScaddenDavid... | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:HanZhong... | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:YangRen ChiRC | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:LiZong JinZJ | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:WangZack ZZZ | lld:pubmed |
| pubmed-article:15786495 | pubmed:author | pubmed-author:ZhengYi... | lld:pubmed |
| pubmed-article:15786495 | pubmed:copyrightInfo | (c) 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15786495 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15786495 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15786495 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:15786495 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15786495 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15786495 | pubmed:pagination | 559-70 | lld:pubmed |
| pubmed-article:15786495 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:meshHeading | pubmed-meshheading:15786495... | lld:pubmed |
| pubmed-article:15786495 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15786495 | pubmed:articleTitle | Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation. | lld:pubmed |
| pubmed-article:15786495 | pubmed:affiliation | State Key Laboratory of Experimental Hematology, National Research Center for Stem Cell Engineering and Technology, Institute of Hematology and Blood Disease Hospital, Tianjin 300020, PR China. | lld:pubmed |
| pubmed-article:15786495 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15786495 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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