| pubmed-article:15783168 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15783168 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:15783168 | lifeskim:mentions | umls-concept:C0137823 | lld:lifeskim |
| pubmed-article:15783168 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:15783168 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15783168 | pubmed:dateCreated | 2005-3-23 | lld:pubmed |
| pubmed-article:15783168 | pubmed:abstractText | We have investigated the structure-activity relationship of cationic amphiphilic polymethacrylate derivatives in antimicrobial and hemolytic assays. The polymers were prepared by radical copolymerizations of N-(tert-butoxycarbonyl)aminoethyl methacrylate and butyl methacrylate in the presence of methyl 3-mercaptopropionate as a chain transfer agent to give precursor polymers protected with a tert-butoxycarbonyl (Boc) group. Subsequent treatment of the Boc-protected polymers with TFA affords the desired cationic random copolymers. We examined antimicrobial and hemolytic activities of a series of polymers having a wide range of mole percentage of butyl groups (0-60%) in three different molecular weight (MW) ranges. The smallest polymers (MW < 2000) showed the lowest MIC and reduced hemolytic activity compared to that of the higher MW ones. In addition, polymers containing a high percentage of butyl groups are less selective for bacterial cells than their less hydrophobic counterparts. | lld:pubmed |
| pubmed-article:15783168 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15783168 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15783168 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15783168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15783168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15783168 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15783168 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15783168 | pubmed:issn | 0002-7863 | lld:pubmed |
| pubmed-article:15783168 | pubmed:author | pubmed-author:DeGradoWillia... | lld:pubmed |
| pubmed-article:15783168 | pubmed:author | pubmed-author:KurodaKenichi... | lld:pubmed |
| pubmed-article:15783168 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15783168 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15783168 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:15783168 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15783168 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15783168 | pubmed:pagination | 4128-9 | lld:pubmed |
| pubmed-article:15783168 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:meshHeading | pubmed-meshheading:15783168... | lld:pubmed |
| pubmed-article:15783168 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15783168 | pubmed:articleTitle | Amphiphilic polymethacrylate derivatives as antimicrobial agents. | lld:pubmed |
| pubmed-article:15783168 | pubmed:affiliation | Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. | lld:pubmed |
| pubmed-article:15783168 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15783168 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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