| pubmed-article:1578282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1578282 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1578282 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1578282 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:1578282 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:1578282 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1578282 | lifeskim:mentions | umls-concept:C0205855 | lld:lifeskim |
| pubmed-article:1578282 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1578282 | pubmed:dateCreated | 1992-6-5 | lld:pubmed |
| pubmed-article:1578282 | pubmed:abstractText | Intracellular recordings were made from presumed dopamine-containing neurons in slices cut from the midbrain of the rat. Focal electrical stimulation produced a hyperpolarizing synaptic potential that was reduced by 75-95% by the GABAB-receptor antagonist 2-hydroxysaclofen (300 microM). 5-HT (3-100 microM) reduced the amplitude of the GABAB synaptic potential by 20-74%, with a 50% reduction at 10 microM, but did not reduce the amplitude of synaptic potentials mediated by GABAA receptors. 5-HT acted presynaptically because hyperpolarizations produced by exogenously administered GABA (1 mM) in picrotoxin (100 microM) were not affected by 5-HT (30 microM). (+/-)-Cyanopindolol (100 nM), a 5-HT1B antagonist, blocked the effect of 5-HT (10 microM); spiperone (1 microM), which is an antagonist at 5-HT1A and 5-HT2 receptors, had no effect. The amplitude of the GABAB synaptic potential was reduced by the 5-HT1B receptor agonists 1-[3-(trifluoromethyl)-phenyl]-piperazine (300 nM) and 7-trifluoromethyl-4-(4-methyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline (1 microM), but not by the 5-HT1A agonist N,N-dipropyl-5-carboxamidotryptamine (1 microM) or the 5-HT2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (10 microM). We conclude that 5-HT activates presynaptic 5-HT1B receptors that inhibit the release of GABA onto GABAB but not GABAA receptors. | lld:pubmed |
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| pubmed-article:1578282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1578282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1578282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1578282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1578282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1578282 | pubmed:month | May | lld:pubmed |
| pubmed-article:1578282 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:1578282 | pubmed:author | pubmed-author:NorthR ARA | lld:pubmed |
| pubmed-article:1578282 | pubmed:author | pubmed-author:JohnsonS WSW | lld:pubmed |
| pubmed-article:1578282 | pubmed:author | pubmed-author:MercuriN BNB | lld:pubmed |
| pubmed-article:1578282 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1578282 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1578282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1578282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1578282 | pubmed:pagination | 2000-6 | lld:pubmed |
| pubmed-article:1578282 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1578282 | pubmed:meshHeading | pubmed-meshheading:1578282-... | lld:pubmed |
| pubmed-article:1578282 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1578282 | pubmed:articleTitle | 5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons. | lld:pubmed |
| pubmed-article:1578282 | pubmed:affiliation | Vollum Institute, Oregon Health Sciences University, Portland 97201. | lld:pubmed |
| pubmed-article:1578282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1578282 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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