| pubmed-article:15781587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0002092 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0023395 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C1334145 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:15781587 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:15781587 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15781587 | pubmed:dateCreated | 2005-3-22 | lld:pubmed |
| pubmed-article:15781587 | pubmed:abstractText | Although dendritic cells (DCs) play an important role in sensitization to inhaled allergens, their function in ongoing T helper (Th)2 cell-mediated eosinophilic airway inflammation underlying bronchial asthma is currently unknown. Here, we show in an ovalbumin (OVA)-driven murine asthma model that airway DCs acquire a mature phenotype and interact with CD4(+) T cells within sites of peribronchial and perivascular inflammation. To study whether DCs contributed to inflammation, we depleted DCs from the airways of CD11c-diphtheria toxin (DT) receptor transgenic mice during the OVA aerosol challenge. Airway administration of DT depleted CD11c(+) DCs and alveolar macrophages and abolished the characteristic features of asthma, including eosinophilic inflammation, goblet cell hyperplasia, and bronchial hyperreactivity. In the absence of CD11c(+) cells, endogenous or adoptively transferred CD4(+) Th2 cells did not produce interleukin (IL)-4, IL-5, and IL-13 in response to OVA aerosol. In CD11c-depleted mice, eosinophilic inflammation and Th2 cytokine secretion were restored by adoptive transfer of CD11c(+) DCs, but not alveolar macrophages. These findings identify lung DCs as key proinflammatory cells that are necessary and sufficient for Th2 cell stimulation during ongoing airway inflammation. | lld:pubmed |
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| pubmed-article:15781587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15781587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15781587 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15781587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15781587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15781587 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15781587 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:HoogstedenHen... | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:DuezCatherine... | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:LambrechtBart... | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:JungSteffenS | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:VosNandaN | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:WillartMoniqu... | lld:pubmed |
| pubmed-article:15781587 | pubmed:author | pubmed-author:KleinjanAlexA | lld:pubmed |
| pubmed-article:15781587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15781587 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15781587 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:15781587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15781587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15781587 | pubmed:pagination | 981-91 | lld:pubmed |
| pubmed-article:15781587 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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