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pubmed-article:15781343pubmed:abstractTextIt is not clear how the transfer of exogenous growth factor genes to tenocytes affects collagen production. An increase in collagen production enhances the repair but an increase in growth factors that stimulate tissue fibrosis may cause adhesion. Gene therapy is a new way to regulate tendon healing but it has been explored rarely. We genetically modified tenocytes with the vascular endothelial growth factor (VEGF) gene and investigated the expression of the genes for collagen production in an in vitro model of the proliferating tenocytes.lld:pubmed
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pubmed-article:15781343pubmed:authorpubmed-author:TangJin BoJBlld:pubmed
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pubmed-article:15781343pubmed:authorpubmed-author:LiuPaul YPYlld:pubmed
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pubmed-article:15781343pubmed:volume30lld:pubmed
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pubmed-article:15781343pubmed:pagination222-9lld:pubmed
pubmed-article:15781343pubmed:dateRevised2009-6-8lld:pubmed
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pubmed-article:15781343pubmed:articleTitleTendon healing in vitro: modification of tenocytes with exogenous vascular endothelial growth factor gene increases expression of transforming growth factor beta but minimally affects expression of collagen genes.lld:pubmed
pubmed-article:15781343pubmed:affiliationDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908-4735, USA.lld:pubmed
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