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pubmed-article:15780606pubmed:abstractTextThe synthesis of several quinolinium salts and related compounds and their ability to inhibit glucocorticoid-induced apoptosis in murine thymocytes are described. Interestingly, 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)ethyl]quinolinium bromide (11) showed a potent protective effect with an EC(50) of 0.013 microM, which was at least 300-fold more potent than the reference compound pifithrin-alpha.lld:pubmed
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pubmed-article:15780606pubmed:articleTitleQuinolinium salt as a potent inhibitor of lymphocyte apoptosis.lld:pubmed
pubmed-article:15780606pubmed:affiliationDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0663, USA.lld:pubmed
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pubmed-article:15780606pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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