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pubmed-article:15778609pubmed:abstractTextMalignant transformation of cells is frequently associated with abnormalities in HLA expression. These abnormalities may play a significant role in the clinical course of the disease because the cellular immune response to tumors relies on concomitant recognition of tumor antigens with self-HLA molecules. Since HLA molecules mediate interactions of tumor cells with specific receptors on T and natural killer (NK) cells, tight control of expression of HLA molecules is critical for initiation and implementation of an effective cellular immune response. There is not much information on HLA class I antigens in conjunctival carcinomas. We studied the immunoexpression of HLA class I antigen and beta2-microglobulin (beta2-m) in conjunctival dysplasias and conjunctival squamous cell carcinomas.lld:pubmed
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pubmed-article:15778609pubmed:pagination337-41lld:pubmed
pubmed-article:15778609pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15778609pubmed:articleTitleHuman leukocyte class I antigen and beta2-microglobulin expression in conjunctival dysplasia, carcinoma in situ, and squamous cell carcinoma.lld:pubmed
pubmed-article:15778609pubmed:affiliationDepartment of Ocular Pathology, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India. drkrishnakumar_2000@yahoo.comlld:pubmed
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