| pubmed-article:15777780 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0017687 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0547070 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C1855585 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:15777780 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:15777780 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15777780 | pubmed:dateCreated | 2005-3-21 | lld:pubmed |
| pubmed-article:15777780 | pubmed:abstractText | Glucagon release upon hypoglycemia is an important homeostatic mechanism utilized by vertebrates to restore blood glucose to normal. Glucagon secretion itself is triggered by Ca2+ influx through voltage-gated ion channels, and the gene inactivation of R-type Ca2+ channels, with Ca(v)2.3 as the ion conducting subunit, has been shown to disturb glucose homeostasis. To understand how glucagon release may be affected in Ca(v)2.3-deficient mice, carbachol, insulin and glucose induced glucagon response was investigated. While the rise of insulin and glucose induced by carbachol is normal, mutant mice show an impaired glucagon-response. Further, the effect of insulin injection on glucagon levels was altered by the loss of the Ca(v)2.3 subunit. Ca(v)2.3-deficient mice are characterized by an impaired glucose suppression of glucagon release. This was most obvious at the level of isolated islets suggesting that Ca(v)2.3 containing R-type voltage-gated Ca2+ channels are involved in the glucose-mediated signalling to glucagon release in mice. | lld:pubmed |
| pubmed-article:15777780 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15777780 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15777780 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15777780 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15777780 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15777780 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15777780 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:SmythNeilN | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:RenströmErikE | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:PereverzevAle... | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:SchneiderToni... | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:HeschelerJürg... | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:MikhnaMarinaM | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:WeiergräberMa... | lld:pubmed |
| pubmed-article:15777780 | pubmed:author | pubmed-author:SalehiAlbertA | lld:pubmed |
| pubmed-article:15777780 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15777780 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15777780 | pubmed:volume | 511 | lld:pubmed |
| pubmed-article:15777780 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15777780 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15777780 | pubmed:pagination | 65-72 | lld:pubmed |
| pubmed-article:15777780 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15777780 | pubmed:meshHeading | pubmed-meshheading:15777780... | lld:pubmed |
| pubmed-article:15777780 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15777780 | pubmed:articleTitle | The ablation of the Ca(v)2.3/E-type voltage-gated Ca2+ channel causes a mild phenotype despite an altered glucose induced glucagon response in isolated islets of Langerhans. | lld:pubmed |
| pubmed-article:15777780 | pubmed:affiliation | Institute of Neurophysiology, University of Cologne, Robert-Koch-Str. 39, D-50931 Köln, Germany; Center of Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 39, D-50931 Köln, Germany. | lld:pubmed |
| pubmed-article:15777780 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15777780 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15777780 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15777780 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12290 | entrezgene:pubmed | pubmed-article:15777780 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15777780 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15777780 | lld:pubmed |
