Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15774622rdf:typepubmed:Citationlld:pubmed
pubmed-article:15774622lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:15774622lifeskim:mentionsumls-concept:C0856825lld:lifeskim
pubmed-article:15774622lifeskim:mentionsumls-concept:C1332714lld:lifeskim
pubmed-article:15774622lifeskim:mentionsumls-concept:C1332701lld:lifeskim
pubmed-article:15774622lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:15774622pubmed:issue1lld:pubmed
pubmed-article:15774622pubmed:dateCreated2005-6-21lld:pubmed
pubmed-article:15774622pubmed:abstractTextWe studied the role of chemokine receptor CCR6 in acute graft-versus-host disease (GvHD), a pathology in which activated, host antigen-specific donor T cells selectively damage tissues such as skin, liver, and gut. GvHD incidence was reduced in major histocompatibility complex (MHC) class II-mismatched recipients of CD4+ T cells from CCR6-deficient donors. In MHC-matched/minor histocompatibility antigen-mismatched recipients of CD4+CD45RB(high) T cells from CCR6-deficient donors, infiltration of CD45+ and CD4+ cells to skin and gut, as well as lesion onset, were significantly delayed, and pathologic symptoms were milder. Consistent with this, in skin and gut of recipients of naive T cells from CCR6-deficient donors we observed lower levels of interferon gamma (IFN-gamma), interleukin 10 (IL-10), and the chemokines that control activated T-cell homing. We suggest a role for CCR6 in recruiting alloreactive CD4+ T cells to target tissues and identify CCR6 as a potential therapeutic target for GvHD.lld:pubmed
pubmed-article:15774622pubmed:languageenglld:pubmed
pubmed-article:15774622pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:citationSubsetAIMlld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15774622pubmed:statusMEDLINElld:pubmed
pubmed-article:15774622pubmed:monthJullld:pubmed
pubmed-article:15774622pubmed:issn0006-4971lld:pubmed
pubmed-article:15774622pubmed:authorpubmed-author:Martínez-ACar...lld:pubmed
pubmed-article:15774622pubmed:authorpubmed-author:GómezLucioLlld:pubmed
pubmed-article:15774622pubmed:authorpubmed-author:MárquezGabrie...lld:pubmed
pubmed-article:15774622pubmed:authorpubmed-author:VaronaRosaRlld:pubmed
pubmed-article:15774622pubmed:authorpubmed-author:CadenasVanesa...lld:pubmed
pubmed-article:15774622pubmed:issnTypePrintlld:pubmed
pubmed-article:15774622pubmed:day1lld:pubmed
pubmed-article:15774622pubmed:volume106lld:pubmed
pubmed-article:15774622pubmed:ownerNLMlld:pubmed
pubmed-article:15774622pubmed:authorsCompleteYlld:pubmed
pubmed-article:15774622pubmed:pagination18-26lld:pubmed
pubmed-article:15774622pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:meshHeadingpubmed-meshheading:15774622...lld:pubmed
pubmed-article:15774622pubmed:year2005lld:pubmed
pubmed-article:15774622pubmed:articleTitleCCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses.lld:pubmed
pubmed-article:15774622pubmed:affiliationDepartamento de Inmunología y Oncología, Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.lld:pubmed
pubmed-article:15774622pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15774622pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:12458entrezgene:pubmedpubmed-article:15774622lld:entrezgene
entrez-gene:14961entrezgene:pubmedpubmed-article:15774622lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15774622lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15774622lld:pubmed