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pubmed-article:15773449pubmed:abstractTextA number of cytokines have been implicated in the pathophysiology of congestive heart failure. Genetic polymorphisms of several cytokine genes are known to result in altered gene expression, enabling us to characterize patients as "high" or "low" producers of specific cytokines. We speculate that the cytokine genotypes for a population of children who underwent heart transplantation for end-stage ventricular failure due to cardiomyopathy or congenital heart disease would be enriched for "high producers" of pro-inflammatory cytokines and "low producers" of anti-inflammatory cytokines.lld:pubmed
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pubmed-article:15773449pubmed:articleTitlePolymorphisms in cytokine genes do not predict progression to end-stage heart failure in children.lld:pubmed
pubmed-article:15773449pubmed:affiliationDepartment of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, PA 15213, USA. steve.webber@chp.edulld:pubmed
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