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pubmed-article:15770146pubmed:abstractTextBeta-catenin, a protein component of adherens junctions, plays a role in the signalling pathway for cell proliferation. In this study, we examined the cellular distribution of beta-catenin in developing auditory epithelia of mice. Immunohistochemistry for Ki67 and cyclin D indicated active cell proliferation in premature auditory epithelia. In this period, the nuclear localization of beta-catenin in epithelial cells was observed together with expression of the lymphoid enhancer factor, a transcription factor in beta-catenin signalling. Epithelial cells showing nuclear localization of beta-catenin disappeared at the same time, as there was a decrease of cell proliferation. These findings indicate that nuclear translocation of beta-catenin plays a role in cell proliferation in developing auditory epithelia.lld:pubmed
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pubmed-article:15770146pubmed:articleTitleNuclear translocation of beta-catenin in developing auditory epithelia of mice.lld:pubmed
pubmed-article:15770146pubmed:affiliationDepartment of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.lld:pubmed
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