| pubmed-article:15767450 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C0872054 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C1880274 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C1553877 | lld:lifeskim |
| pubmed-article:15767450 | lifeskim:mentions | umls-concept:C1608885 | lld:lifeskim |
| pubmed-article:15767450 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15767450 | pubmed:dateCreated | 2005-3-15 | lld:pubmed |
| pubmed-article:15767450 | pubmed:abstractText | The Epstein-Barr virus (EBV) nuclear antigen 3B (EBNA-3B) is considered nonessential for EBV-mediated B-cell growth transformation in vitro based on three virus isolates with EBNA-3B mutations. Two of these isolates could potentially express truncated EBNA-3B products, and, similarly, we now show that the third isolate, IB4, has a point mutation and in-frame deletion of 263 amino acids. In order to test whether a virus with EBNA-3B completely deleted can immortalize B-cell growth, we first cloned the EBV genome as a bacterial artificial chromosome (BAC) and showed that the BAC-derived virus was B-cell immortalization competent. Deletion of the entire EBNA-3B open reading frame from the EBV BAC had no adverse impact on growth of EBV-immortalized B cells, providing formal proof that EBNA-3B is not essential for EBV-mediated B-cell growth transformation in vitro. | lld:pubmed |
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| pubmed-article:15767450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15767450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15767450 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15767450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15767450 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15767450 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15767450 | pubmed:author | pubmed-author:QuinkCarolC | lld:pubmed |
| pubmed-article:15767450 | pubmed:author | pubmed-author:WangFredF | lld:pubmed |
| pubmed-article:15767450 | pubmed:author | pubmed-author:ChenAdrienneA | lld:pubmed |
| pubmed-article:15767450 | pubmed:author | pubmed-author:JiangXiaoqunX | lld:pubmed |
| pubmed-article:15767450 | pubmed:author | pubmed-author:DivisconteMat... | lld:pubmed |
| pubmed-article:15767450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15767450 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:15767450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15767450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15767450 | pubmed:pagination | 4506-9 | lld:pubmed |
| pubmed-article:15767450 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15767450 | pubmed:meshHeading | pubmed-meshheading:15767450... | lld:pubmed |
| pubmed-article:15767450 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15767450 | pubmed:articleTitle | Epstein-Barr virus with the latent infection nuclear antigen 3B completely deleted is still competent for B-cell growth transformation in vitro. | lld:pubmed |
| pubmed-article:15767450 | pubmed:affiliation | Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. | lld:pubmed |
| pubmed-article:15767450 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15767450 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15767450 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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