| pubmed-article:15766947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C0600542 | lld:lifeskim |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C0059374 | lld:lifeskim |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C0013125 | lld:lifeskim |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C1704243 | lld:lifeskim |
| pubmed-article:15766947 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:15766947 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15766947 | pubmed:dateCreated | 2005-3-15 | lld:pubmed |
| pubmed-article:15766947 | pubmed:abstractText | The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (V(ss)=5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t(1/2beta)=2.66 h and MRT=1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR+CIP). | lld:pubmed |
| pubmed-article:15766947 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15766947 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766947 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15766947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15766947 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15766947 | pubmed:issn | 0034-5288 | lld:pubmed |
| pubmed-article:15766947 | pubmed:author | pubmed-author:NavarroJ LJL | lld:pubmed |
| pubmed-article:15766947 | pubmed:author | pubmed-author:RodríguezCC | lld:pubmed |
| pubmed-article:15766947 | pubmed:author | pubmed-author:San AndrésM... | lld:pubmed |
| pubmed-article:15766947 | pubmed:author | pubmed-author:de LucasJ JJJ | lld:pubmed |
| pubmed-article:15766947 | pubmed:author | pubmed-author:MartellaM BMB | lld:pubmed |
| pubmed-article:15766947 | pubmed:author | pubmed-author:LábaqueM CMC | lld:pubmed |
| pubmed-article:15766947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15766947 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:15766947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15766947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15766947 | pubmed:pagination | 265-7 | lld:pubmed |
| pubmed-article:15766947 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:meshHeading | pubmed-meshheading:15766947... | lld:pubmed |
| pubmed-article:15766947 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15766947 | pubmed:articleTitle | Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study. | lld:pubmed |
| pubmed-article:15766947 | pubmed:affiliation | Departmento de Toxicología y Farmacología, Cátedra de Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/ Puerta de Hierro s.n., 28040 Madrid, Spain. delucas@vet.ucm.es | lld:pubmed |
| pubmed-article:15766947 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15766947 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
