| pubmed-article:15755809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C0549183 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C0061928 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C0683283 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C2828633 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C2828360 | lld:lifeskim |
| pubmed-article:15755809 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:15755809 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15755809 | pubmed:dateCreated | 2005-3-23 | lld:pubmed |
| pubmed-article:15755809 | pubmed:abstractText | The regulators of the Rho-family GTPases, GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs), play important roles in axon guidance. By means of a functional genomic study of the Rho-family GEFs and GAPs in Drosophila, we have identified a Rho-family GAP, CrossGAP (CrGAP), which is involved in Roundabout (Robo) receptor-mediated repulsive axon guidance. CrGAP physically associates with the Robo receptor. Too much or too little CrGAP activity leads to defects in Robo-mediated repulsion at the midline choice point. The CrGAP gain-of-function phenotype mimics the loss-of-function phenotypes of both Robo and Rac. Dosage-sensitive genetic interactions among CrGAP, Robo, and Rac support a model in which CrGAP transduces signals downstream of Robo receptor to regulate Rac-dependent cytoskeletal changes. | lld:pubmed |
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| pubmed-article:15755809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15755809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755809 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15755809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15755809 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15755809 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:LiMingM | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:LabradorJuan-... | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:GoodmanCorey... | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:LaiEric CEC | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:BashawGreg... | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:McEwenJasonJ | lld:pubmed |
| pubmed-article:15755809 | pubmed:author | pubmed-author:HuHailanH | lld:pubmed |
| pubmed-article:15755809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15755809 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:15755809 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:15755809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15755809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15755809 | pubmed:pagination | 4613-8 | lld:pubmed |
| pubmed-article:15755809 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15755809 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15755809 | pubmed:articleTitle | Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. | lld:pubmed |
| pubmed-article:15755809 | pubmed:affiliation | Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. | lld:pubmed |
| pubmed-article:15755809 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15755809 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15755809 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15755809 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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