| pubmed-article:15755677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C0962722 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C1723136 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C1869507 | lld:lifeskim |
| pubmed-article:15755677 | lifeskim:mentions | umls-concept:C2354310 | lld:lifeskim |
| pubmed-article:15755677 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15755677 | pubmed:dateCreated | 2005-3-9 | lld:pubmed |
| pubmed-article:15755677 | pubmed:abstractText | Short fragments and fragment analogues of beta-amyloid 1-42 peptide (Abeta1-42) display a protective effect against Abeta-mediated neurotoxicity. After consideration of our earlier results with in vitro bioassay of synthetic Abeta-recognition peptides and toxic fibrillar amyloids, five pentapeptides were selected as putative neuroprotective agents: Phe-Arg-His-Asp-Ser amide (Abeta4-8) and Gly-Arg-His-Asp-Ser amide (an analogue of Abeta4-8), Leu-Pro-Tyr-Phe-Asp amide (an analogue of Abeta17-21), Arg-Ile-Ile-Gly-Leu amide (an analogue of Abeta30-34), and Arg-Val-Val-Ile-Ala amide (an analogue of Abeta38-42). In vitro electrophysiological experiments on rat brain slices demonstrated that four of these peptides counteracted with the field excitatory postsynaptic potential-attenuating effect of Abeta1-42; only Arg-Val-Val-Ile-Ala amide proved inactive. In in vivo experiments using extracellular single-unit recordings combined with iontophoresis, all these pentapeptides except Arg-Val-Val-Ile-Ala amide protected neurons from the NMDA response-enhancing effect of Abeta1-42 in the hippocampal CA1 region. These results suggest that Abeta recognition sequences may serve as leads for the design of novel neuroprotective compounds. | lld:pubmed |
| pubmed-article:15755677 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15755677 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15755677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15755677 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15755677 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:KisZZ | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:FarkasTT | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:SoósKK | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:MolnárZZ | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:HorváthSS | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:PenkeBB | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:FülöpLL | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:BudaiDD | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:ToldiJJ | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:ZarándiMM | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:PenkeZZ | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:RózsaEE | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:RobotkaHH | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:SzegediVV | lld:pubmed |
| pubmed-article:15755677 | pubmed:author | pubmed-author:DatkiZZ | lld:pubmed |
| pubmed-article:15755677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15755677 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15755677 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15755677 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15755677 | pubmed:pagination | 499-508 | lld:pubmed |
| pubmed-article:15755677 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:meshHeading | pubmed-meshheading:15755677... | lld:pubmed |
| pubmed-article:15755677 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15755677 | pubmed:articleTitle | Pentapeptides derived from Abeta 1-42 protect neurons from the modulatory effect of Abeta fibrils--an in vitro and in vivo electrophysiological study. | lld:pubmed |
| pubmed-article:15755677 | pubmed:affiliation | Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged H-6720, Hungary. szegv@yahoo.com | lld:pubmed |
| pubmed-article:15755677 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15755677 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15755677 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15755677 | lld:pubmed |
