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pubmed-article:15753616pubmed:abstractTextRecent reports have proved that genetic factors play a role in the pathogenesis of sporadic Parkinson's disease (PD). It has been suggested that polymorphisms in monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) might increase the risk of PD. A total of 210 Polish patients with sporadic PD and 152 healthy controls were studied. The MAOB and COMT polymorphisms were identified using the polymerase chain reaction-restriction fragment length polymorphism method. The MAOB allele and genotype frequencies in PD patients did not differ significantly from the controls. A statistically lower frequency of the COMTLL genotype in patients with parkinsonism was found. The combined haplotype of the MAOB G (G/G) and COMTHL genotype showed a fourfold increase (p < 0.05) in the risk of PD in female patients in this Polish population.lld:pubmed
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pubmed-article:15753616pubmed:copyrightInfoCopyright 2005 S. Karger AG, Basel.lld:pubmed
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pubmed-article:15753616pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15753616pubmed:articleTitleCatechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population.lld:pubmed
pubmed-article:15753616pubmed:affiliationDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.lld:pubmed
pubmed-article:15753616pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15753616pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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