| pubmed-article:15752762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15752762 | lifeskim:mentions | umls-concept:C0169904 | lld:lifeskim |
| pubmed-article:15752762 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:15752762 | lifeskim:mentions | umls-concept:C1424810 | lld:lifeskim |
| pubmed-article:15752762 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15752762 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:15752762 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15752762 | pubmed:dateCreated | 2005-3-8 | lld:pubmed |
| pubmed-article:15752762 | pubmed:abstractText | The C-terminal portion of the Plasmodium falciparum blood stage MSP-1 antigen plays a key role in invasion of human erythrocytes. The MSP-1(1282-1301) non-polymorphic 1585 peptide, from the processed MSP-1(42) fragment, is poorly immunogenic and highly alpha-helical [Angew. Chem. Int. Ed. 40 (2001) 4654]. Assessing the alpha-carbon asymmetry and its implication in the host immune response is proposed in this work to overcome the 1585 peptide's immunological properties. Accordingly, the effect of incorporating single D-amino acids and psi-[CH(2)-NH] isoster bonds into the 1585 peptide was examined both at the immunogenic and 3D-structure levels. Therefore, specific binding to RBCs is promoted by site-directed chiral modifications on the native peptide as well as by simultaneously combining specific D-substitutions with psi-[CH(2)-NH] isoster bonds transforming this molecule into a high specific HLAbeta1*1101 allele binder. D-analog pseudopeptide immunized animals induced antibodies selectively recognizing a recombinant as well as native MSP-1(42) and MSP-1(33) fragments. Protection and low parasitemia levels were induced in Aotus monkeys immunized with the EVLYL(dK)PLAGVYRSLKKQLE analog. Peptide alpha-carbon chiral transformation is therefore an important target for structural modulation and, consequently, represents a novel approach towards designing multi-component subunit-based malarial vaccines. | lld:pubmed |
| pubmed-article:15752762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15752762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15752762 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15752762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15752762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15752762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15752762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15752762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15752762 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15752762 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:VeraRicardoR | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:TorresElizabe... | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:PatarroyoManu... | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:EspejoFabiola... | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:LozanoJosé... | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:SilvaYolandaY | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:VargasLuis... | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:CortésJimenaJ | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:RosasJaiverJ | lld:pubmed |
| pubmed-article:15752762 | pubmed:author | pubmed-author:LesmesLiliana... | lld:pubmed |
| pubmed-article:15752762 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15752762 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15752762 | pubmed:volume | 329 | lld:pubmed |
| pubmed-article:15752762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15752762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15752762 | pubmed:pagination | 1053-66 | lld:pubmed |
| pubmed-article:15752762 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15752762 | pubmed:meshHeading | pubmed-meshheading:15752762... | lld:pubmed |
| pubmed-article:15752762 | pubmed:meshHeading | pubmed-meshheading:15752762... | lld:pubmed |
| pubmed-article:15752762 | pubmed:meshHeading | pubmed-meshheading:15752762... | lld:pubmed |
| pubmed-article:15752762 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15752762 | pubmed:articleTitle | Protection against malaria induced by chirally modified Plasmodium falciparum's MSP-1 42 pseudopeptides. | lld:pubmed |
| pubmed-article:15752762 | pubmed:affiliation | Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D.C., Colombia. jm_lozano@fidic.org.co | lld:pubmed |
| pubmed-article:15752762 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15752762 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15752762 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
