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pubmed-article:15743503pubmed:abstractTextSulfotransferase 1A1 (encoded by SULT1A1) is involved in the metabolism of procarcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are present in tobacco smoke. We recently reported a differential effect of N-acetyltransferase (NAT) 2 genotype on the association between active and passive smoking and breast cancer. Additional investigation of a common SULT1A1 genetic polymorphism associated with reduced enzyme activity and stability might therefore provide deeper insight into the modification of breast cancer susceptibility.lld:pubmed
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pubmed-article:15743503pubmed:articleTitleSULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study.lld:pubmed
pubmed-article:15743503pubmed:affiliationDivision of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany. c.lilla@dkfz-heidelberg.delld:pubmed
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