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pubmed-article:15742804rdf:typepubmed:Citationlld:pubmed
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pubmed-article:15742804pubmed:issue1lld:pubmed
pubmed-article:15742804pubmed:dateCreated2005-3-3lld:pubmed
pubmed-article:15742804pubmed:abstractTextSeven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root of Aralia cordata. Their chemical structures were determined as (-)-pimara-8(14),15-dien-19-oic acid (2), pimaric acid (3), (-)-kaur-16-en-19-oic acid (4), 17-hydroxy-ent-kaur-15-en-19-oic acid (9), 7alpha-hydroxy-(-)-pimara-8(14),15-dien-19-oic acid (10), 16alpha,17-dihydroxy-(-)-kauran-19-oic acid (11), 16-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid (12), falcarindiol (5), dehydrofalcarindiol (6), dehydrofalcarindiol-8-acetate (7), falcarindiol-8-acetate (8), alpha-mono palmitin (13), stigmasterol (1), and daucosterol (14) by the spectral evidences. These compounds were tested with COX-1 and COX-2 inhibition assays. This study found that compounds 2, 4, 5, 6, 7, 8, and 10 inhibited COX-1 dependent conversion of the exogenous arachidonic acid to PGE2 in a dose-dependent manner with IC50 values of 134.2 microM, 121.6 microM, 170 microM, 50.4 microM, 11.7 microM, 99.6 microM, and 69.6 microM, respectively. But, most of these compounds weakly inhibited COX-2 dependent PGE2 generation. Among them, only compound 4 showed relatively significant inhibitory activity (IC50: 127.6 microM).lld:pubmed
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pubmed-article:15742804pubmed:issn0253-6269lld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:BaeKiHwanKlld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:KimHyun PyoHPlld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:SonKun HoKHlld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:ChangHyeun...lld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:KangSam SikSSlld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:DangNguyen...lld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:ZhangXinFengXlld:pubmed
pubmed-article:15742804pubmed:authorpubmed-author:ZhengMingShan...lld:pubmed
pubmed-article:15742804pubmed:issnTypePrintlld:pubmed
pubmed-article:15742804pubmed:volume28lld:pubmed
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pubmed-article:15742804pubmed:authorsCompleteYlld:pubmed
pubmed-article:15742804pubmed:pagination28-33lld:pubmed
pubmed-article:15742804pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:15742804pubmed:meshHeadingpubmed-meshheading:15742804...lld:pubmed
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pubmed-article:15742804pubmed:year2005lld:pubmed
pubmed-article:15742804pubmed:articleTitleInhibitory constituents against cyclooxygenases from Aralia cordata Thunb.lld:pubmed
pubmed-article:15742804pubmed:affiliationCollege of Pharmacy, Chungnam National University, Taejon 305-764, Korea.lld:pubmed
pubmed-article:15742804pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15742804pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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