| pubmed-article:15735649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C1833235 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:15735649 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:15735649 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15735649 | pubmed:dateCreated | 2005-3-23 | lld:pubmed |
| pubmed-article:15735649 | pubmed:abstractText | The p38 MAP kinase (MAPK) is phosphorylated and activated by upstream MAPK kinases. T cells have an alternative pathway in which T cell receptor-activated tyrosine kinase Zap70 phosphorylates p38 on Tyr323. Mice lacking Gadd45alpha, a small p38-binding molecule, develop a lupus-like autoimmune disease. Here we show that resting T cells but not B cells from Gadd45a(-/-) mice had spontaneously increased p38 activity in the absence of 'upstream' MAPK kinase activation. The p38 from resting Gadd45a(-/-) T cells was spontaneously phosphorylated on Tyr323, and its activity was specifically inhibited by recombinant Gadd45alpha in vitro. Thus, constitutive activation of T cell p38 through the alternative pathway is prevented by Gadd45alpha, the absence of which results in p38 activation, T cell hyperproliferation and autoimmunity. | lld:pubmed |
| pubmed-article:15735649 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15735649 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15735649 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15735649 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15735649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15735649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15735649 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15735649 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:15735649 | pubmed:author | pubmed-author:BelovaGalina... | lld:pubmed |
| pubmed-article:15735649 | pubmed:author | pubmed-author:FornaceAlbert... | lld:pubmed |
| pubmed-article:15735649 | pubmed:author | pubmed-author:AshwellJonath... | lld:pubmed |
| pubmed-article:15735649 | pubmed:author | pubmed-author:MittelstadtPa... | lld:pubmed |
| pubmed-article:15735649 | pubmed:author | pubmed-author:SalvadorJesus... | lld:pubmed |
| pubmed-article:15735649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15735649 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:15735649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15735649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15735649 | pubmed:pagination | 396-402 | lld:pubmed |
| pubmed-article:15735649 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15735649 | pubmed:meshHeading | pubmed-meshheading:15735649... | lld:pubmed |
| pubmed-article:15735649 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15735649 | pubmed:articleTitle | The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. | lld:pubmed |
| pubmed-article:15735649 | pubmed:affiliation | Gene Response Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:15735649 | pubmed:publicationType | Journal Article | lld:pubmed |
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