| pubmed-article:15733669 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15733669 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15733669 | lifeskim:mentions | umls-concept:C0230960 | lld:lifeskim |
| pubmed-article:15733669 | lifeskim:mentions | umls-concept:C0002938 | lld:lifeskim |
| pubmed-article:15733669 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:15733669 | lifeskim:mentions | umls-concept:C0205281 | lld:lifeskim |
| pubmed-article:15733669 | lifeskim:mentions | umls-concept:C1706701 | lld:lifeskim |
| pubmed-article:15733669 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15733669 | pubmed:dateCreated | 2005-2-28 | lld:pubmed |
| pubmed-article:15733669 | pubmed:abstractText | Through an unusual differentiation process, human trophoblast progenitors (cytotrophoblasts) give rise to tumor-like cells that invade the uterus. By an unknown mechanism, invasive cytotrophoblasts exhibit permanent cell cycle withdrawal. Here, we report molecular cytogenetic data showing that approximately 20 to 60% of these interphase cells had acquired aneusomies involving chromosomes X, Y, or 16. The incidence positively correlated with gestational age and differentiation to an invasive phenotype. Scoring 12 chromosomes in flow-sorted cytotrophoblasts showed that more than 95% of the cells were hyperdiploid. Thus, aneuploidy appears to be an important component of normal placentation, perhaps limiting the proliferative and invasive potential of cytotrophoblasts within the uterus. | lld:pubmed |
| pubmed-article:15733669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15733669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15733669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15733669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15733669 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15733669 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15733669 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15733669 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15733669 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15733669 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15733669 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:ZhouYanY | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:FisherSusan... | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:WeierHeinz-Ul... | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:ChuLisa WLW | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:GenbacevOlgaO | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:WeierJingly... | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:WrightAlexi... | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:JungChristine... | lld:pubmed |
| pubmed-article:15733669 | pubmed:author | pubmed-author:GormleyMatthe... | lld:pubmed |
| pubmed-article:15733669 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15733669 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15733669 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15733669 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15733669 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15733669 | pubmed:pagination | 420-32 | lld:pubmed |
| pubmed-article:15733669 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
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| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
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| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:meshHeading | pubmed-meshheading:15733669... | lld:pubmed |
| pubmed-article:15733669 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15733669 | pubmed:articleTitle | Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. | lld:pubmed |
| pubmed-article:15733669 | pubmed:affiliation | Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143-0720, USA. | lld:pubmed |
| pubmed-article:15733669 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15733669 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15733669 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15733669 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15733669 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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