Loss of occlusal function has been reported to induce atrophic changes in the periodontal ligament. It is likely that mechanical stress triggers the biological response of periodontal ligament. However, there have been few reports studying the correlation between mechanical stress of varying magnitude and periodontal ligament cell activities such as extracellular matrix (ECM) synthesis.
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Gradute School, Tokyo Medical and Dental University, Tokyo, Japan. shu.orts@tmd.ac.jp
