| pubmed-article:15728473 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:15728473 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:15728473 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15728473 | pubmed:dateCreated | 2005-2-24 | lld:pubmed |
| pubmed-article:15728473 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15728473 | pubmed:abstractText | CD4(+) regulatory T (Treg) cells play an important role in the maintenance of immunological self-tolerance by suppressing immune responses against autoimmune diseases and cancer. Yet very little is known about the natural antigenic ligands that preferentially activate CD4(+) Treg cells. Here we report the establishment of tumor-specific CD4(+) Treg cell clones from tumor-infiltrating lymphocytes (TILs) of cancer patients, and the identification of an Ag recognized by Treg cells (ARTC1) gene encoding a peptide ligand recognized by tumor-specific TIL164 CD4(+) Treg cells. The mutations in a gene encoding an ARTC1 in 164mel tumor cells resulted in the translation of a gene product containing the peptide ligand recognized by CD4(+) Treg cells. ARTC1 peptide-activated CD4(+) Treg cells suppress the physiological function (proliferation and IL-2 secretion) of melanoma-reactive T cells. Furthermore, 164mel tumor cells, but not tumor lysates pulsed on B cells, were capable of activating TIL164 CD4(+) Treg cells. These results suggest that tumor cells may uniquely present an array of peptide ligands that preferentially recruit and activate CD4(+) Treg cells in sites where tumor-specific self-peptide is expressed, leading to the induction of local and tumor-specific immune suppression. | lld:pubmed |
| pubmed-article:15728473 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15728473 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15728473 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15728473 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15728473 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15728473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15728473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15728473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15728473 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15728473 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15728473 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15728473 | pubmed:author | pubmed-author:ShevachEthan... | lld:pubmed |
| pubmed-article:15728473 | pubmed:author | pubmed-author:WangRong-FuRF | lld:pubmed |
| pubmed-article:15728473 | pubmed:author | pubmed-author:WangHelen YHY | lld:pubmed |
| pubmed-article:15728473 | pubmed:author | pubmed-author:GuoZhongZ | lld:pubmed |
| pubmed-article:15728473 | pubmed:author | pubmed-author:PengGuangyong... | lld:pubmed |
| pubmed-article:15728473 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15728473 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15728473 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15728473 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15728473 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15728473 | pubmed:pagination | 2661-70 | lld:pubmed |
| pubmed-article:15728473 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15728473 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15728473 | pubmed:articleTitle | Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells. | lld:pubmed |
| pubmed-article:15728473 | pubmed:affiliation | Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:15728473 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15728473 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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