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| pubmed-article:15718306 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15718306 | lifeskim:mentions | umls-concept:C0877373 | lld:lifeskim |
| pubmed-article:15718306 | lifeskim:mentions | umls-concept:C0675974 | lld:lifeskim |
| pubmed-article:15718306 | lifeskim:mentions | umls-concept:C0920321 | lld:lifeskim |
| pubmed-article:15718306 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15718306 | pubmed:dateCreated | 2005-2-18 | lld:pubmed |
| pubmed-article:15718306 | pubmed:abstractText | We determined the maximum-tolerated dose (MTD) and the dose-limiting toxicities (DLT) of 17-allylamino-17-demethoxygeldanamycin (17-AAG) when infused on days 1, 8, and 15 of a 28-day cycle in advanced solid tumor patients. We also characterized the pharmacokinetics of 17-AAG, its effect on chaperone and client proteins, and whether cytochrome P450 (CYP) 3A5 and NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphisms affected 17-AAG disposition or toxicity. | lld:pubmed |
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| pubmed-article:15718306 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15718306 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15718306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15718306 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15718306 | pubmed:issn | 0732-183X | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:ToftDavidD | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:ErlichmanChar... | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:SloanJeffJ | lld:pubmed |
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| pubmed-article:15718306 | pubmed:author | pubmed-author:GoetzMatthew... | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:AmesMatthewM | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:AdjeiAlexA | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:VasileVladV | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:ReidJoelJ | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:StensgardBrid... | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:SafgrenStepha... | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:SalazaarSandr... | lld:pubmed |
| pubmed-article:15718306 | pubmed:author | pubmed-author:CroghanGaryG | lld:pubmed |
| pubmed-article:15718306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15718306 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:15718306 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:15718306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15718306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15718306 | pubmed:pagination | 1078-87 | lld:pubmed |
| pubmed-article:15718306 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15718306 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15718306 | pubmed:articleTitle | Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. | lld:pubmed |
| pubmed-article:15718306 | pubmed:affiliation | Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA. | lld:pubmed |
| pubmed-article:15718306 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15718306 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15718306 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15718306 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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