| pubmed-article:15715458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15715458 | lifeskim:mentions | umls-concept:C0028953 | lld:lifeskim |
| pubmed-article:15715458 | lifeskim:mentions | umls-concept:C1099354 | lld:lifeskim |
| pubmed-article:15715458 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:15715458 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:15715458 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:15715458 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15715458 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15715458 | pubmed:dateCreated | 2005-2-17 | lld:pubmed |
| pubmed-article:15715458 | pubmed:abstractText | We have identified a small interfering RNA (siRNA) motif, consisting entirely of 2'-O-methyl and 2'-fluoro nucleotides, that displays enhanced plasma stability and increased in vitro potency. At one site, this motif showed remarkable >500-fold improvement in potency over the unmodified siRNA. This marks the first report of such a potent fully modified motif, which may represent a useful design for therapeutic oligonucleotides. | lld:pubmed |
| pubmed-article:15715458 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15715458 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15715458 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15715458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15715458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15715458 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15715458 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:PrakashThazha... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:GriffeyRichar... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:SwayzeEric... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:SioufiNamirN | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:BhatBalkrishe... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:AllersonCharl... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:JarresRussell... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:NaikNishantN | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:BerdejaAndres... | lld:pubmed |
| pubmed-article:15715458 | pubmed:author | pubmed-author:WandersLisaL | lld:pubmed |
| pubmed-article:15715458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15715458 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:15715458 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:15715458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15715458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15715458 | pubmed:pagination | 901-4 | lld:pubmed |
| pubmed-article:15715458 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15715458 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15715458 | pubmed:articleTitle | Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA. | lld:pubmed |
| pubmed-article:15715458 | pubmed:affiliation | Department of Medicinal Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA. callerson@isisph.com | lld:pubmed |
| pubmed-article:15715458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15715458 | pubmed:publicationType | Comparative Study | lld:pubmed |
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