| pubmed-article:15713437 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C0546837 | lld:lifeskim |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C0388911 | lld:lifeskim |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C0024232 | lld:lifeskim |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15713437 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:15713437 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15713437 | pubmed:dateCreated | 2005-2-16 | lld:pubmed |
| pubmed-article:15713437 | pubmed:abstractText | Hypoxia inducible factor (HIF)-1alpha is a transcription factor that regulates the transcription of genes associated with cell proliferation and vascular development. In various cancer tissues, HIF-1alpha is associated with clinicopathological factors, such as the tumor size, histological grade, and lymph node status. Although HIF-1alpha plays a critical role in tumor growth by inducing vascular endothelial growth factor (VEGF), it is unclarified whether HIF-1alpha affects lymphatic metastasis. The purpose of this study is to clarify the correlation of HIF-1alpha protein expression with lymph node metastasis in esophageal squamous cell carcinoma (ESCC). The expressions of HIF-1alpha and VEGF-C, which is one of the main lymphangiogenic factors, were examined in five ESCC cell lines and 48 surgical specimens of ESCC. HIF-1alpha and VEGF-C mRNAs were expressed in all the five ESCC cell lines as determined by RT-PCR analysis. Immunohistochemically, 34 of the 48 patients (70.8%) were positive for HIF-1alpha and 29 patients (60.4%) were positive for VEGF-C. Clinicopathologically, HIF-1alpha expression correlated with lymphatic invasion and VEGF-C expression (P = 0.003 and P = 0.01, respectively). Furthermore, HIF-1alpha expression tended to correlate with lymph node metastasis (P = 0.09). These findings suggest that HIF-1alpha plays a role in lymphatic invasion and lymph node metastasis through the induction of VEGF-C in ESCC. | lld:pubmed |
| pubmed-article:15713437 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15713437 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15713437 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15713437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15713437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15713437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15713437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15713437 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15713437 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15713437 | pubmed:issn | 0014-4800 | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:NomuraTsutomu... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:IshiwataToshi... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:TajiriTakashi... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:NaitoZenyaZ | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:KudoMitsuhiro... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:YamashitaKiyo... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:MiyashitaMasa... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:MakinoHiroshi... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:KatsutaMiwako... | lld:pubmed |
| pubmed-article:15713437 | pubmed:author | pubmed-author:ShinjiSeiichi... | lld:pubmed |
| pubmed-article:15713437 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15713437 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:15713437 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15713437 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15713437 | pubmed:pagination | 123-30 | lld:pubmed |
| pubmed-article:15713437 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:15713437 | pubmed:meshHeading | pubmed-meshheading:15713437... | lld:pubmed |
| pubmed-article:15713437 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15713437 | pubmed:articleTitle | Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. | lld:pubmed |
| pubmed-article:15713437 | pubmed:affiliation | Surgery for Organ Function and Biological Regulation (Department of Surgery I), Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. mkatsuta@nms.ac.jp | lld:pubmed |
| pubmed-article:15713437 | pubmed:publicationType | Journal Article | lld:pubmed |
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