Linked Life Data

15708846

Source:http://linkedlifedata.com/resource/pubmed/id/15708846

Statements in which the resource exists.
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pubmed-article:15708846pubmed:abstractTextThe relaxin-like factor (RLF) is thought to be responsible for the intra-abdominal migration of the testis during mammalian development. Our latest studies of RLF and LGR8 have revealed that the N-terminal region of the A chain is not required for receptor binding but is indispensable for cyclic AMP generation. RLF derivatives with six residues deleted from the N terminus of the A chain are active, whereas further truncation, up to the first A chain cysteine (A-10), yields tightly binding ligands devoid of signaling activity. These derivatives are specific competitive inhibitors (RLFi) of RLF. Although receptor binding is dependent upon B chain residues, the N-terminal region of the A chain is a generic trigger of the trans-membrane signaling activity.lld:pubmed
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pubmed-article:15708846pubmed:articleTitleLGR8 signal activation by the relaxin-like factor.lld:pubmed
pubmed-article:15708846pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston South Carolina 29425, USA. bullesee@musc.edulld:pubmed
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