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pubmed-article:15705348pubmed:abstractTextOne of the most demanding tasks in psychiatry is to protect patients from suicidal attempts. Preventive strategies could be improved by increasing our knowledge on the pathophysiologic disturbances underlying this behavior. More than 70-80% of suicides occur in the context of depressive disorders, in which dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis is one of the most prominent neurobiological findings. So far data on the involvement of the HPA axis in the pathophysiology of suicidal behavior in depressed patients are controversial.lld:pubmed
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pubmed-article:15705348pubmed:articleTitleHypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression.lld:pubmed
pubmed-article:15705348pubmed:affiliationMax-Planck Institute of Psychiatry, Munich, Germany. andrea.pfennig@charite.delld:pubmed
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