| pubmed-article:15704140 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15704140 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:15704140 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15704140 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15704140 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15704140 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:15704140 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15704140 | pubmed:dateCreated | 2005-4-25 | lld:pubmed |
| pubmed-article:15704140 | pubmed:abstractText | LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding that LAF-4 expression is tissue specific, we did not detect any LAF-4 mRNA in normal mammary epithelial cell lines. However, 2 of 5 breast cancer cell lines were found to express LAF-4 at both the RNA and protein levels. In 2 of 9 primary tumor-normal pairs, the expression of LAF-4 was clearly elevated in the tumor tissue. Using RNA in situ hybridization, we demonstrated that LAF-4 is expressed in mammary tumor cells but not in normal acini. In a group of 64 primary human breast tumors, we found that LAF-4 was overexpressed in approximately 20% of the cases. Although epigenetic changes may be involved in altered expression of some genes, differences in LAF-4 expression were not associated with DNA methylation of the predicted promoter region. Our results suggest that LAF-4 may be a proto-oncogene that is transcriptionally activated in some cases of breast cancer. | lld:pubmed |
| pubmed-article:15704140 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15704140 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15704140 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15704140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15704140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15704140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15704140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15704140 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15704140 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15704140 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:15704140 | pubmed:author | pubmed-author:AndrulisIrene... | lld:pubmed |
| pubmed-article:15704140 | pubmed:author | pubmed-author:GokgozNalanN | lld:pubmed |
| pubmed-article:15704140 | pubmed:author | pubmed-author:PinnaduwageDu... | lld:pubmed |
| pubmed-article:15704140 | pubmed:author | pubmed-author:ToMinh DMD | lld:pubmed |
| pubmed-article:15704140 | pubmed:author | pubmed-author:FaserukStepha... | lld:pubmed |
| pubmed-article:15704140 | pubmed:author | pubmed-author:DoneSusan JSJ | lld:pubmed |
| pubmed-article:15704140 | pubmed:copyrightInfo | Copyright 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15704140 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15704140 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15704140 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:15704140 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15704140 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15704140 | pubmed:pagination | 568-74 | lld:pubmed |
| pubmed-article:15704140 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
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| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:meshHeading | pubmed-meshheading:15704140... | lld:pubmed |
| pubmed-article:15704140 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15704140 | pubmed:articleTitle | LAF-4 is aberrantly expressed in human breast cancer. | lld:pubmed |
| pubmed-article:15704140 | pubmed:affiliation | Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:15704140 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15704140 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15704140 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3899 | entrezgene:pubmed | pubmed-article:15704140 | lld:entrezgene |
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