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pubmed-article:15701778pubmed:abstractTextAdverse effects are the most common cause for failure of an antiepileptic drug (AED), especially when an AED is added to existing therapy. With the increased drug load, it may not be possible to titrate the newly added AED to effective doses. Reducing the dosage of AED cotherapy as the new drug is introduced may improve tolerability.lld:pubmed
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pubmed-article:15701778pubmed:articleTitleEffect of cotherapy reduction on tolerability of epilepsy add-on therapy: a randomized controlled trial.lld:pubmed
pubmed-article:15701778pubmed:affiliationSchool of Medicine, Southern Illinois University, PO Box 19637, Springfield, IL 62794-9637, USA. dnaritoku@siumed.edulld:pubmed
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