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pubmed-article:15696248pubmed:abstractTextLong-term success of endovascular aneurysm repair (EVAR) relies on a stable proximal neck. The authors' goal was to determine whether neck dilatation after EVAR varies among 4 different endografts and whether it is related to complications of the proximal neck. Core laboratory data from 4 phase II trials of aortic endografts were analyzed for neck diameter changes over time. Patients who had at least 24 months' follow-up were included in the analysis. Neck measurement methodology varied among the 3 core labs used. Values are reported within the parameters used by each lab. Short-axis neck diameter close to 5 mm below the renal arteries, when available, was used for longitudinal comparisons. Dilation was defined as an enlargement of 3 mm or more from the first postoperative scan to the last available follow-up for each patient. Graft migration and late proximal endoleaks were determined by the individual core labs. A limited number of Lifepath grafts had most recent follow-up measurements performed by the authors. Results were compared by using Student's t test, chi-square analysis, and the Pearson correlation coefficient. Postoperative measurements from 729 EVAR patients were examined. Follow-up ranged from 24 to 60 months for 229 Ancure (Guidant) and 258 AneuRx (Medtronic) patients, and from 24 to 36 months for 211 Excluder (Gore) and 31 first-generation Lifepath (Edwards) patients. Neck dilation was noted in 124 patients (17.0%) and did not differ significantly among graft types. The incidences of late proximal endoleaks were similar among graft types, but rates of migration differed (p=0.01). Dilation was associated with migration in Ancure (p=0.03) and Excluder (p=0.02) grafts. Late proximal endoleaks were seen in 4.1% of patients with and in 0.7% of patients without dilation (p=0.001). Patients with initial neck diameter >25 mm had significantly less dilatation than those with smaller necks (p<0.001). The incidence of neck dilation approached 20% in all EVAR patients after 24 months and was not significantly different among graft types. Neck dilation of 3 mm or more appears to be one risk factor for migration and late proximal endoleak.lld:pubmed
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pubmed-article:15696248pubmed:issn1538-5744lld:pubmed
pubmed-article:15696248pubmed:authorpubmed-author:MakarounMiche...lld:pubmed
pubmed-article:15696248pubmed:authorpubmed-author:DillavouEllen...lld:pubmed
pubmed-article:15696248pubmed:authorpubmed-author:MulukSatishSlld:pubmed
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pubmed-article:15696248pubmed:volume39lld:pubmed
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pubmed-article:15696248pubmed:pagination47-54lld:pubmed
pubmed-article:15696248pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:15696248pubmed:articleTitleIs neck dilatation after endovascular aneurysm repair graft dependent? Results of 4 US Phase II trials.lld:pubmed
pubmed-article:15696248pubmed:affiliationDivision of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.lld:pubmed
pubmed-article:15696248pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15696248pubmed:publicationTypeComparative Studylld:pubmed