pubmed-article:15695583 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C0520990 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
pubmed-article:15695583 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
pubmed-article:15695583 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:15695583 | pubmed:dateCreated | 2005-2-16 | lld:pubmed |
pubmed-article:15695583 | pubmed:abstractText | Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the model Drosophila melanogaster to dissect and identify early host responses that function in the initiation and progression of Pseudomonas aeruginosa pathogenesis. First, we use immune potentiation and genetic studies to demonstrate that flies mount a heightened defense against the highly virulent P. aeruginosa strain PA14 when first inoculated with strain CF5, which is avirulent in flies; this effect is mediated via the Imd and Toll signaling pathways. Second, we use whole-genome expression profiling to assess and compare the Drosophila early defense responses triggered by the PA14 vs. CF5 strains to identify genes whose expression patterns are different in susceptible vs. resistant host-pathogen interactions, respectively. Our results identify pathogenesis- and defense-specific genes and uncover a previously undescribed mechanism used by P. aeruginosa in the initial stages of its host interaction: suppression of Drosophila defense responses by limiting antimicrobial peptide gene expression. These results provide insights into the genetic factors that mediate or restrict pathogenesis during the early stages of the bacterial-host interaction to advance our understanding of P. aeruginosa-human infections. | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:language | eng | lld:pubmed |
pubmed-article:15695583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15695583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15695583 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15695583 | pubmed:month | Feb | lld:pubmed |
pubmed-article:15695583 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:RahmeLaurence... | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:DavisRonald... | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:XiaoWenzhongW | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:BaldiniRegina... | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:LauGee WGW | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:MindrinosMich... | lld:pubmed |
pubmed-article:15695583 | pubmed:author | pubmed-author:ApidianakisYi... | lld:pubmed |
pubmed-article:15695583 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15695583 | pubmed:day | 15 | lld:pubmed |
pubmed-article:15695583 | pubmed:volume | 102 | lld:pubmed |
pubmed-article:15695583 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15695583 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15695583 | pubmed:pagination | 2573-8 | lld:pubmed |
pubmed-article:15695583 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:meshHeading | pubmed-meshheading:15695583... | lld:pubmed |
pubmed-article:15695583 | pubmed:year | 2005 | lld:pubmed |
pubmed-article:15695583 | pubmed:articleTitle | Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. | lld:pubmed |
pubmed-article:15695583 | pubmed:affiliation | Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. | lld:pubmed |
pubmed-article:15695583 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15695583 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:31046 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:31155 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:31166 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:32548 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:32794 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33000 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33022 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33251 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33474 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33727 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33752 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:33764 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:34044 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:34052 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:35007 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:35841 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36009 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36047 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36188 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36195 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36316 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36351 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36635 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36636 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36637 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36708 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36753 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:36927 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:37099 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:37132 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:37183 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:37184 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:37206 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:37905 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38058 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38125 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38126 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38127 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38128 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38241 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38370 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38419 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38684 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38710 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38757 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:38839 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:39002 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:39075 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:39179 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:39870 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40149 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40185 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40210 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40444 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40548 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40745 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40824 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:40836 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:41087 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:41169 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:41195 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:41330 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:41718 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:41885 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:42450 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:42721 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:42852 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43036 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43177 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43256 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43596 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43597 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43598 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43599 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43662 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:43767 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:44339 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:45247 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:45326 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:45668 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:48316 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:48583 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:50022 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:50433 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:53432 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:2768720 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:3771968 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
entrez-gene:3772576 | entrezgene:pubmed | pubmed-article:15695583 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15695583 | lld:pubmed |