| pubmed-article:15694263 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C0152035 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C0008286 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C1333253 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15694263 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15694263 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15694263 | pubmed:dateCreated | 2005-2-7 | lld:pubmed |
| pubmed-article:15694263 | pubmed:abstractText | Previous studies have demonstrated that the -141C Ins/Del and TaqI A polymorphisms in the DRD2 gene affect the density of the dopamine D2 receptor. The present study examines the correlation between these two polymorphisms and the therapeutic response to chlorpromazine, a typical antipsychotic drug, in 135 inpatients with schizophrenia. Clinical symptoms were evaluated using the Brief Psychiatry Rating Scale (BPRS) before and after 8 weeks of treatment with 300-600 mg/day of chlorpromazine. Our results show that genotyping -141C Ins/Del may help to predict the efficacy of chlorpromazine treatment (P=0.01) due to the fact that patients with no Del allele showed greater improvement than those with Del allele on the overall BPRS (P=0.03), and that, therefore, the potential for therapy in patients with schizophrenia is related to the -141C Ins/Del polymorphism in the DRD2 gene. However, no such relationship was found for the TaqI A polymorphism. | lld:pubmed |
| pubmed-article:15694263 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15694263 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15694263 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15694263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15694263 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15694263 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15694263 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:GuNiufanN | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:FengGuoyinG | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:HeLinL | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:LiXingwangX | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:GaoRuiR | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:XingQingheQ | lld:pubmed |
| pubmed-article:15694263 | pubmed:author | pubmed-author:WuShengnanS | lld:pubmed |
| pubmed-article:15694263 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15694263 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15694263 | pubmed:volume | 376 | lld:pubmed |
| pubmed-article:15694263 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15694263 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15694263 | pubmed:pagination | 1-4 | lld:pubmed |
| pubmed-article:15694263 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15694263 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15694263 | pubmed:articleTitle | Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. | lld:pubmed |
| pubmed-article:15694263 | pubmed:affiliation | Bio-X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China. | lld:pubmed |
| pubmed-article:15694263 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15694263 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15694263 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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